DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut3 and Slc2a4

DIOPT Version :9

Sequence 1:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_036883.1	Gene:	Slc2a4 / 25139	RGDID:	2711	Length:	509	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	135/527 - (25%)
Similarity:	215/527 - (40%)	Gaps:	114/527 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GIQD--AEPVEPPQSSRKSGTWFAKRPSEMPERHVERAPVRQKINNVGLYKATLYSNIGSFFFGI 67
            |.|.  :|..|||| .|.:||                           |..|...:.:||..||.
  Rat     4 GFQQIGSEDGEPPQ-QRVTGT---------------------------LVLAVFSAVLGSLQFGY 40

  Fly    68 AVGWSGTAERSVMEQHSYSFQPTEL------------------QWSGVCILLTLGAALWCLPMGL 114
            .:|.. .|.:.|:||   |:..|.|                  .|:....:.::|..:....:|:
  Rat    41 NIGVI-NAPQKVIEQ---SYNATWLGRQGPGGPDSIPQGTLTTLWALSVAIFSVGGMISSFLIGI 101

  Fly   115 MVRLLGCRRTILIQLLPNFLGWFLTVFAR---SVPMLYAGRFFLGMCGGAHCVVVPIYNAEISTT 176
            :.:.||.:|.:|...:...||..|...|.   |..:|..|||.:|...|....:||:|..||:.|
  Rat   102 ISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGLVPMYVGEIAPT 166

  Fly   177 KKRGAMGVVFEGACICGVIYSFAMSLFLELRIINFVNLGLLALGP-----------LQILM---- 226
            ..|||:|.:.:.|.:.|::  .|..|.||..      ||...|.|           ||:|:
  Rat   167 HLRGALGTLNQLAIVIGIL--VAQVLGLESM------LGTATLWPLLLAITVLPALLQLLLLPFC 223

  Fly   227 PESPAY-YVDHGNIPRAEDSLRFLRG---------QKYDTRREIDFLTRDPTESEREVRQGPLLG 281
            ||||.| |:.......|..||:.|.|         :..|.:|::        |.||.:....|||
  Rat   224 PESPRYLYIIRNLEGPARKSLKRLTGWADVSDALAELKDEKRKL--------ERERPLSLLQLLG 280

  Fly   282 FKYKKVRRSLARSLAIALLQKLCGALIFIFYGLNMLDCLRIRREFGLILCLGLI--LGFLACFFL 344
            .:..  |:.|..::.:.|.|:|.|.....:|..::.:...:.:.....:..|::  :..|....|
  Rat   281 SRTH--RQPLIIAVVLQLSQQLSGINAVFYYSTSIFELAGVEQPAYATIGAGVVNTVFTLVSVLL 343

  Fly   345 VDRLGRRPLLIFSSAGIVFVSIYLGLHFKVWMTMGLTV------MSWIALFCIAIFVGCYTAGVG 403
            |:|.|||.|.:...||:...:|.        ||:.|.:      ||::::..|..||..:..|.|
  Rat   344 VERAGRRTLHLLGLAGMCGCAIL--------MTVALLLLERVPSMSYVSIVAIFGFVAFFEIGPG 400

  Fly   404 SLTWVLNAELLVRPMRPLGCSIVCAFNWLTAFFVICWFGSHGVKCQPYLFLLFAIIASLILLFSL 468
            .:.|.:.|||..:..||...::....||...|.|...|........||:|||||::.....:|:.
  Rat   401 PIPWFIVAELFSQGPRPAAMAVAGFSNWTCNFIVGMGFQYVADAMGPYVFLLFAVLLLGFFIFTF 465

  Fly   469 IYIPETK 475
            :.:|||:
  Rat   466 LRVPETR 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	123/470 (26%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	50/194 (26%)
Slc2a4	NP_036883.1	Interaction with SRFBP1. /evidence=ECO:0000250\|UniProtKB:P14672	7..13		1/5 (20%)
		Sugar_tr	27..483	CDD:278511	124/476 (26%)
		MFS	78..447	CDD:119392	100/394 (25%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	298..304		3/5 (60%)
		Dileucine internalization motif. /evidence=ECO:0000255	489..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337791
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840