DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut3 and Slc2a6

DIOPT Version :9

Sequence 1:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_766247.2	Gene:	Slc2a6 / 227659	MGIID:	2443286	Length:	497	Species:	Mus musculus

Alignment Length:	500	Identity:	131/500 - (26%)
Similarity:	229/500 - (45%)	Gaps:	71/500 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 FAKRPSEMPERHVERAPVRQKINNVGLYKATLYSNIGSFFFGIAVGWSGTA--ERSVMEQHSYSF 87
            |.:.|:...||  |||..   :.|..::.||..:.:|:|.||.|:.::...  |..:....:...
Mouse    16 FPEVPATPGER--ERAGA---LKNRRVFLATFAAVLGNFSFGYALVYTSPVIPELKLSSDPALHL 75

  Fly    88 QPTELQWSGVCILLTLGAALWCLPMGLMVRLLGCRRTILIQLLPNFLGWFLTVFARSVPMLYAGR 152
            ...:..|.|  .:.|||||...|...|:..|||.:.:|:...:|:.:|:.:...||.:.||..||
Mouse    76 DKIQASWFG--SVFTLGAAAGGLSAMLLNDLLGRKLSIMFSAVPSAIGYAIMAGARGLWMLLLGR 138

  Fly   153 FFLGMCGGAHCVVVPIYNAEISTTKKRGAMGVVFEGACICGVIYSFAMSLFLELRIINFVNLGLL 217
            ...|..||.....:|:|.:||:....|||:|...:...:.|.:..:|:.|.|..|.     |.:.
Mouse   139 MLTGFAGGLTAACIPVYVSEIAPPDVRGALGATPQLMAVFGSLSLYALGLLLPWRW-----LAVA 198

  Fly   218 ALGPLQIL------MPESPAYYVDHGNIPRAEDSLRFLRGQK---YDTRREIDFLTRDPTE-SER 272
            ..||:.|:      ||.||.:.:.......|..:|.:||...   ::..:..|.:.|..:. |..
Mouse   199 GEGPVLIMILLLSFMPNSPRFLLSKSRDEEALQALTWLRADSEVHWEFEQIQDNVRRQSSRVSWA 263

  Fly   273 EVRQGPLLGFKYKKVRRSLARSLAIALLQKLCGALIFIFYGLNMLD----CLRIRREFGLILCLG 333
            |.|:        .:|.|.:..::.:..||:|.|....:.|...:.|    .|..:::..::..:.
Mouse   264 EARE--------PRVYRPVLIAVLMRFLQQLTGITPILVYLQTIFDNTSVVLPSQQDAAIVGAVR 320

  Fly   334 LILGFLACFFLVDRLGRRPLLIFSSAGIVF-VSIYLGLHFKV------------WMTMGLTVMSW 385
            | |..|.....:|..||: :|::.||.::| .::.|||:.:.            .:|:|.|..::
Mouse   321 L-LSVLIAAVTMDLAGRK-VLLYVSASVMFAANLTLGLYVQFVPRPLTPNSTVEIVTLGDTAFNY 383

  Fly   386 ---IALFCIAIFVGCYTAGVGSLTWVLNAELLVRPMRPLG-----CSIVCAFNWLTAFFVICWF- 441
               |.|....:|:..|..|.|.:||:|.:|:|  |:|..|     |.:|   :|||||.:..:|
Mouse   384 LTLIPLLATMLFIMGYAMGWGPITWLLMSEVL--PLRARGVASGLCVLV---SWLTAFVLTNYFL 443

  Fly   442 ---GSHGVKCQPYLFLLFAIIASLILLFSLIYIPETKKLSSAKIQ 483
               .:.|::. |:.|  |:.|..|.|||:...:|||:..|..:|:
Mouse   444 LAVNAFGLQV-PFFF--FSAICLLSLLFTGCCVPETRGRSLEQIE 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	121/464 (26%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	46/170 (27%)
Slc2a6	NP_766247.2	Dileucine internalization motif. /evidence=ECO:0000255	5..6
		MFS	38..483	CDD:391944	122/469 (26%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	284..290		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834224
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	1	1.000	-	-		FOG0000275
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850