Protein Alignment Glut3 and SLC2A12

DIOPT Version :9

• Sequence 1: NP_536732.1
• Gene: Glut3 / 42036
• FlyBaseID: FBgn0015230
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_660159.1
• Gene: SLC2A12 / 154091
• HGNCID: 18067
• Length: 617
• Species: Homo sapiens
• Alignment Length: 590
• Identity: 121/590 - (20%)
• Similarity: 219/590 - (37%)
• Gaps: 143/590 - (24%)

  Fly    10 EPVEPPQSSRKSGTWFAKRPSEMPERHVERAPVRQKINNVGLYKATLYSNIGSFFFGIAVGW--- 71
            |..|.|....:.||  |........||...|      ...|::  |..|::.:...|:.||:
Human     5 ENTEGPSLLNQKGT--AVETEGSGSRHPPWA------RGCGMF--TFLSSVTAAVSGLLVGYELG 59

  Fly    72 --SGTAERSVMEQHSYSFQPTELQWSGVCILLTLGAALWCLPMGLMVRLLGCRRTILIQLLPNFL 134
              || |...:....:.|....|:    |...|.:||.|..|..|:::...|.|..|::......|
Human    60 IISG-ALLQIKTLLALSCHEQEM----VVSSLVIGALLASLTGGVLIDRYGRRTAIILSSCLLGL 119

  Fly   135 GWFLTVFARSVPMLYAGRFFLGMCGGAHCVVVPIYNAEISTTKKRGAMGVVFEGACICGVI---- 195
            |..:.:.:.|..:|..||..:|:......:...:|.|||:...:||.:..:.|...:.|::
Human   120 GSLVLILSLSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILSAYI 184

  Fly   196 --YSFAMSLFLELRIINFVNLGL-LALGPLQIL----MPESPAYYVDHGNIPRAEDSLRFLRGQK 253
              |:|| ::|...:.:    .|| :.||.||.:    :|.||.:.|..|....|...|..||...
Human   185 SNYAFA-NVFHGWKYM----FGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEGAASKVLGRLRALS 244

  Fly   254 YDTRREIDFLTRDPTESEREVRQGPLLGFKYK-KVRRSLARSLAIALLQKLCGALIFIFYGLNML 317
             ||..|:..: :...:.|.:.....|  |:.| .:|..:...|.:....::.|....:||...:|
Human   245 -DTTEELTVI-KSSLKDEYQYSFWDL--FRSKDNMRTRIMIGLTLVFFVQITGQPNILFYASTVL 305

  Fly   318 DCLRIR-REFGLILCLGL----ILGFLACFFLVDRLGRRPLLIFSSA---------GIVFVSIYL 368
            ..:..: .|...:...|:    ::..:....|||.:|.:..|...|:         |||.::|::
Human   306 KSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCIGSSVMAASLVTMGIVNLNIHM 370

  Fly   369 GL----------------------------------HFK-------------------------- 373
            ..                                  |||
Human   371 NFTHICRSHNSINQSLDESVIYGPGNLSTNNNTLRDHFKGISSHSRSSLMPLRNDVDKRGETTSA 435

  Fly   374 VWMTMGLT---------------VMSWIALFCIAIFVGCYTAGVGSLTWVLNAELLVRPMRPLGC 423
            ..:..||:               .:.|::|..:.::|..::.|:|.:.|::.:|:....:|....
Human   436 SLLNAGLSHTEYQIVTDPGDVPAFLKWLSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAM 500

  Fly   424 SIVCAFNW-------LTAFFVICWFGSHGVKCQPYLFLLFAIIASLILLFSLIYIPETKKLSSAK 481
            ::..:.||       ||...|....|      .|::..::.|::...|||.:::|||||..|..:
Human   501 ALTSSMNWGINLLISLTFLTVTDLIG------LPWVCFIYTIMSLASLLFVVMFIPETKGCSLEQ 559

  Fly   482 IQQRL 486
            |...|
Human   560 ISMEL 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	108/536 (20%)
		MFS	63..>226	CDD:119392	43/178 (24%)
SLC2A12	NP_660159.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		6/25 (24%)
		Sugar_tr	44..561	CDD:306568	107/536 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144038
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840