DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut3 and slc2a8

DIOPT Version :9

Sequence 1:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	XP_031747102.1	Gene:	slc2a8 / 100486943	XenbaseID:	XB-GENE-492572	Length:	503	Species:	Xenopus tropicalis

Alignment Length:	479	Identity:	125/479 - (26%)
Similarity:	213/479 - (44%)	Gaps:	54/479 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 INNVGLYKATLYSNIGSFFFGIAVGWS--GTAERSVMEQHSYSFQPTELQWSGVCILLTLGAALW 108
            :.|..||.||..:.:|...||.|:|:|  ..||.:.::....:.......|.|  .::|:|||..
Frog    29 VQNKNLYLATFAAVLGPLSFGFALGYSSPAIAELTNVDDPRLALDKDAASWFG--SIVTIGAAAG 91

  Fly   109 CLPMGLMVRLLGCRRTILIQLLPNFLGWFLTVFARSVPMLYAGRFFLGMCGGAHCVVVPIYNAEI 173
            .:..|.:|..:|.:.::::..||..||:.|.|.|::|.||..||...|:..|...:|||:|.:|.
Frog    92 GIFGGWIVDRIGRKLSLMLCALPFVLGFTLIVSAQNVWMLLLGRLMTGLASGVTSLVVPVYISET 156

  Fly   174 STTKKRGAMGVVFEGACICGVIYSFAMSLFLELRIINFVNLGLLALGP------LQILMPESPAY 232
            |.::.||.:|...:...:.|::.|:...:.|:.|.     |.:|...|      |...|||:|.|
Frog   157 SHSRVRGTLGSCVQLMVVTGIVGSYIAGMLLDWRW-----LAVLCCIPPVFMVILMCFMPETPRY 216

  Fly   233 YVDHGNIPRAEDSLRFLRGQKYDTRREIDFLTRDPTESEREVRQGPLLGFKYKKVRRSLARSLAI 297
            .:.......|..:|:||||...|...|...:.....:.|..:....|   :...:.:.....:.:
Frog   217 LIQQDKTSEAMAALKFLRGPNADHEWEYRQIESSGDDQETSLAFSEL---RSPAIYKPFLIGIFM 278

  Fly   298 ALLQKLCGALIFIFYGLNMLDCLRIRREFGLILCLGLI-LGFLA-CFFLVDRLGRRPLLIFS--- 357
            ...|:..|....:||...:.:....:......:.:||: :.|.| ...:||:.||:.||..|
Frog   279 MFFQQFTGINAIMFYADTIFEEANFKNSSLASVIVGLVQVAFTAVAAMIVDKAGRKVLLFISGII 343

  Fly   358 ---SAGIVFVSIYLGLHFKVWMTM------------GLTV-----MSWIALFCIAIFVGCYTAGV 402
               |||:      ..::||:..|:            |..:     ::|:||..:.:|:..:..|.
Frog   344 MAISAGV------FAIYFKLTTTVVNNSSGLQSLATGTPISPVDHLAWLALASMGLFIAGFAIGW 402

  Fly   403 GSLTWVLNAELLVRPMRPLG-CSIVCAF-NWLTAFFVICWFGSHGVKCQPY-LFLLFAIIASLIL 464
            |.:.|::.:|:.  |:|..| .|.||.. ||..||.|...|....|....| .|.|||...:|.:
Frog   403 GPIPWLIMSEIF--PLRARGVASGVCVVTNWGCAFLVTKEFHELMVSLTSYGTFGLFAGFCALNV 465

  Fly   465 LFSLIYIPETKKLSSAKIQQRLGG 488
            ||:...:||||..:..:|:....|
Frog   466 LFTAFCVPETKGKTLEQIEAHFRG 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	119/459 (26%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	47/170 (28%)
slc2a8	XP_031747102.1	MFS	35..482	CDD:421695	121/464 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	1	1.000	-	-		FOG0000275
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.110