Protein Alignment Ubx and Nkx6-1

DIOPT Version :10

• Sequence 1: NP_536752.1
• Gene: Ubx / 42034
• FlyBaseID: FBgn0003944
• Length: 389
• Species: Drosophila melanogaster
• Sequence 2: NP_113925.1
• Gene: Nkx6-1 / 65193
• RGDID: 69318
• Length: 365
• Species: Rattus norvegicus
• Alignment Length: 279
• Identity: 73/279 - (26%)
• Similarity: 101/279 - (36%)
• Gaps: 72/279 - (25%)

  Fly   129 GAGNANGGNAANANGQNNPAGGMPVRPSACTPDSRVGGYLDTSGGSPVSHRGGSAGGNVSVSGGN 193
            ||.|. ||....|.|..:..|..|.:.||.||.    |..|......:....|:|..:.|.||.:
  Rat    65 GAHNP-GGLKPPAAGGLSSLGSPPQQLSAATPH----GINDILSRPSMPVASGAALPSASPSGSS 124

  Fly   194 GNAGGVQSGVGVAGAGTAWNANCTISGAAAQTAAASSLHQASNHTFYPWMAIAG-------ECPE 251
            .::....|....:.|..|        .|||..|||||          |...:||       ..|.
  Rat   125 SSSSSSASATSASAAAAA--------AAAAAAAAASS----------PAGLLAGLPRFSSLSPPP 171

  Fly   252 DPTKSKIRSDLTQYGGISTDMGKRYSESLA------------------------------GSLLP 286
            .|..............:.     ||.:.||                              ||:|
  Rat   172 PPPGLYFSPSAAAVAAVG-----RYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSIL- 230

  Fly   287 DWLGTNGLRRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLK 351
              |..:|.|:..|.|::..|...|||.|....||....|..:|::|.:||.|:|:||||||.|.:
  Rat   231 --LDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWR 293

  Fly   352 K----EIQAIKELNEQEKQ 366
            |    |:...|:..:.|.:
  Rat   294 KKHAAEMATAKKKQDSETE 312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubx	NP_536752.1	Homeodomain	296..352	CDD:459649	23/55 (42%)
Nkx6-1	NP_113925.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..136		21/75 (28%)
		Repressor domain. /evidence=ECO:0000250	102..269		41/192 (21%)
		Homeodomain	236..294	CDD:459649	24/57 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..365		3/18 (17%)
		Involved in DNA-binding. /evidence=ECO:0000250	307..365		1/6 (17%)