Protein Alignment Ubx and NKX2-4

DIOPT Version :10

• Sequence 1: NP_536752.1
• Gene: Ubx / 42034
• FlyBaseID: FBgn0003944
• Length: 389
• Species: Drosophila melanogaster
• Sequence 2: NP_149416.1
• Gene: NKX2-4 / 644524
• HGNCID: 7837
• Length: 354
• Species: Homo sapiens
• Alignment Length: 282
• Identity: 65/282 - (23%)
• Similarity: 105/282 - (37%)
• Gaps: 92/282 - (32%)

  Fly   151 MPVRPSACTPDS-------------RVGGYLDTSG---GSPVSHRGGSAGGNVSVSGGNGNA--- 196
            |.:.|...||.|             :..|.:|.:.   |:|:   |.:|.......|.:..|
Human     1 MSLSPKHTTPFSVSDILSPIEETYKKFSGAMDGAPPGLGAPL---GAAAAYRAPPPGPSSQAATV 62

  Fly   197 GGVQSGVGVAGAGTAWNANCTISGAAAQTAAASSLHQASNHTFYPWMAIAGECPEDPTKSKIRSD 261
            .|:|....:||    .||....:.|||..|||::.|.....:.:|..|:...|
Human    63 AGMQPSHAMAG----HNAAAAAAAAAAAAAAAATYHMPPGVSQFPHGAMGSYC------------ 111

  Fly   262 LTQYGGISTDMGK--RYSESLAGSLLPDWLGTN---------------------------GL--- 294
               .||:. :||:  .|::.:.|.....|.|.|                           |:
Human   112 ---NGGLG-NMGELPAYTDGMRGGAATGWYGANPDPRYSSISRFMGPSAGVNVAGMGSLTGIADA 172

  Fly   295 ----------------RRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWF 343
                            ||:.|..:::.|..|||:.|....||:...|..:|..:.||..|:||||
Human   173 AKSLGPLHAAAAAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWF 237

  Fly   344 QNRRMKLKKEI--QAIKELNEQ 363
            ||.|.|:|::.  :|.::|.::
Human   238 QNHRYKMKRQAKDKAAQQLQQE 259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubx	NP_536752.1	Homeodomain	296..352	CDD:459649	22/55 (40%)
NKX2-4	NP_149416.1	Homeodomain	190..246	CDD:459649	22/55 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..329		2/14 (14%)