Protein Alignment Ubx and NKX3-2

DIOPT Version :10

• Sequence 1: NP_536752.1
• Gene: Ubx / 42034
• FlyBaseID: FBgn0003944
• Length: 389
• Species: Drosophila melanogaster
• Sequence 2: NP_001180.1
• Gene: NKX3-2 / 579
• HGNCID: 951
• Length: 333
• Species: Homo sapiens
• Alignment Length: 294
• Identity: 72/294 - (24%)
• Similarity: 105/294 - (35%)
• Gaps: 81/294 - (27%)

  Fly   136 GNAANANGQNNPAG---GMPVRPSAC-------TPDSRVGGYLDTSGGSPVSHRGGSAGGNV--- 187
            |..|...|:..|.|   .:...|:.|       .....:||..|:...||...|  :|.|..
Human    25 GGLAAPEGRPAPGGTAASVAAAPAVCCWRLFGERDAGALGGAEDSLLASPAGTR--TAAGRTAES 87

  Fly   188 --------SVSGGNGNAGGVQSGVGVAGAGTAWNANCTISGAAAQTAAASSLHQASNHTFYPWMA 244
                    ::|..|.:........|.:|||.| ..:.::.....:.||:..|.:.:
Human    88 PEGWDSDSALSEENESRRRCADARGASGAGLA-GGSLSLGQPVCELAASKDLEEEA--------- 142

  Fly   245 IAGECPEDPTKSKIRSDLTQYGGISTDMGKRYSESLAG------SLLPDWLGTNG---------- 293
             ||           |||......:|.|...|..:...|      |.|....|..|
Human   143 -AG-----------RSDSEMSASVSGDRSPRTEDDGVGPRGAHVSALCSGAGGGGGSGPAGVAEE 195

  Fly   294 ---------LRRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMK 349
                     .::|.|..::..|..|||:.|:...||:...|.::|.:|.|||.|:||||||||.|
Human   196 EEEPAAPKPRKKRSRAAFSHAQVFELERRFNHQRYLSGPERADLAASLKLTETQVKIWFQNRRYK 260

  Fly   350 LKKEIQAIKELNEQEKQAQAQKAAAAAAAAAAVQ 383
            .|:...|...|           |:|.||...||:
Human   261 TKRRQMAADLL-----------ASAPAAKKVAVK 283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubx	NP_536752.1	Homeodomain	296..352	CDD:459649	25/55 (45%)
NKX3-2	NP_001180.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	65..113		9/49 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	138..212		16/94 (17%)
		Homeodomain	207..263	CDD:459649	25/55 (45%)