Protein Alignment Ubx and NKX6-1

DIOPT Version :10

• Sequence 1: NP_536752.1
• Gene: Ubx / 42034
• FlyBaseID: FBgn0003944
• Length: 389
• Species: Drosophila melanogaster
• Sequence 2: NP_006159.2
• Gene: NKX6-1 / 4825
• HGNCID: 7839
• Length: 367
• Species: Homo sapiens
• Alignment Length: 281
• Identity: 71/281 - (25%)
• Similarity: 107/281 - (38%)
• Gaps: 74/281 - (26%)

  Fly   135 GGNAANANGQNNPAGGMPVRPSACTPDSRVGGYLDTSGGSPVSHRGGSAGGNVSVSGGNGNAGGV 199
            ||....|.|..:..|..|.:.||.||.    |..|......:....|:|..:.|.||.:.::
Human    70 GGLKPPATGGLSSLGSPPQQLSAATPH----GINDILSRPSMPVASGAALPSASPSGSSSSS--- 127

  Fly   200 QSGVGVAGAGTAWNANCTISGAAAQTAAASSLHQASNHTFYPWMAIAG-------ECPEDPTKSK 257
                  :.:.:|.:|:...:.|||..|||||          |...:||       ..|..|....
Human   128 ------SSSASASSASAAAAAAAAAAAAASS----------PAGLLAGLPRFSSLSPPPPPPGLY 176

  Fly   258 IRSDLTQYGGISTDMGKRYSESLA------------------------------GSLLPDWLGTN 292
            ..........:.     ||.:.||                              ||:|   |..:
Human   177 FSPSAAAVAAVG-----RYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSIL---LDKD 233

  Fly   293 GLRRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLKK----E 353
            |.|:..|.|::..|...|||.|....||....|..:|::|.:||.|:|:||||||.|.:|    |
Human   234 GKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAE 298

  Fly   354 IQAIKELNEQEKQAQAQKAAA 374
            :...|:  :|:.:.:..|.|:
Human   299 MATAKK--KQDSETERLKGAS 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubx	NP_536752.1	Homeodomain	296..352	CDD:459649	23/55 (42%)
NKX6-1	NP_006159.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..133		17/75 (23%)
		Repressor domain. /evidence=ECO:0000250	102..268		40/192 (21%)
		Homeodomain	235..293	CDD:459649	24/57 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..367		5/26 (19%)
		Involved in DNA-binding. /evidence=ECO:0000250	306..367		3/12 (25%)