Protein Alignment Ubx and NKX2-2

DIOPT Version :10

• Sequence 1: NP_536752.1
• Gene: Ubx / 42034
• FlyBaseID: FBgn0003944
• Length: 389
• Species: Drosophila melanogaster
• Sequence 2: NP_002500.1
• Gene: NKX2-2 / 4821
• HGNCID: 7835
• Length: 273
• Species: Homo sapiens
• Alignment Length: 218
• Identity: 57/218 - (26%)
• Similarity: 81/218 - (37%)
• Gaps: 45/218 - (20%)

  Fly   193 NGNAGGVQSGVGVAGAGTAWNANCTISGAAAQTAAAS-----SLHQASNHTFYPWMA-------- 244
            |...|.|..|......|..........|..|..|..|     ..:.:|::.:..|:|
Human    22 NDEEGSVAEGPEEENEGPEPAKRAGPLGQGALDAVQSLPLKNPFYDSSDNPYTRWLASTEGLQYS 86

  Fly   245 ----IAGECPEDPTKSKIRSDLTQYGGISTDMGKRYSESLAGSLLPDWLGTNGLRRRGRQTYTRY 305
                .||..|:|.:.........:    |.|..|   |:..|.      |..|.:|:.|..:::.
Human    87 LHGLAAGAPPQDSSSKSPEPSADE----SPDNDK---ETPGGG------GDAGKKRKRRVLFSKA 138

  Fly   306 QTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLKK-------EIQ-------- 355
            ||.|||:.|....||:...|..:|..:.||..|:||||||.|.|:|:       |:.
Human   139 QTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTPLPSPRRV 203

  Fly   356 AIKELNEQEKQAQAQKAAAAAAA 378
            |:..|....|...|.||...|||
Human   204 AVPVLVRDGKPCHALKAQDLAAA 226

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubx	NP_536752.1	Homeodomain	296..352	CDD:459649	23/55 (42%)
NKX2-2	NP_002500.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56		7/33 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..131		12/53 (23%)
		Homeodomain	129..185	CDD:459649	23/55 (42%)