DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ubx and HOXA3

DIOPT Version :9

Sequence 1:	NP_536752.1	Gene:	Ubx / 42034	FlyBaseID:	FBgn0003944	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_001371264.1	Gene:	HOXA3 / 3200	HGNCID:	5104	Length:	443	Species:	Homo sapiens

Alignment Length:	314	Identity:	90/314 - (28%)
Similarity:	116/314 - (36%)	Gaps:	113/314 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 ANGGNAANANGQNNPAG------GMPVRPSACTPDSRVGGYLDTSGGSPVSHRGGSAGGNVSVSG 191
            |..|.|.|||.|..||.      |...|| ||:..|.     .::||.|.:|....|
Human    20 AANGFAYNANQQPYPASAALGADGEYHRP-ACSLQSP-----SSAGGHPKAHELSEA-------- 70

  Fly   192 GNGNAGGVQSGVGVAGAGTAWNANC--TISGAAAQ------------------------------ 224
                                    |  |:|...:|
Human    71 ------------------------CLRTLSAPPSQPPSLGEPPLHPPPPQAAPPAPQPPQPAPQP 111

  Fly   225 ----------TAAASSLHQASNHTFYPWMAIAGECP--EDPTKSK--------IRSDLTQYGGIS 269
                      .::||....|||:   |..|.|.:.|  ..||.:|        .|.:..|....|
Human   112 PAPTPAAPPPPSSASPPQNASNN---PTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTSSS 173

  Fly   270 TDMGKRYSESLAGSLLPDWLGTNGLRRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCL 334
            :.     .||.||...|....::   :|.|..||..|.:|||||||.|.||.|.||:|||:.|.|
Human   174 SS-----GESCAGDKSPPGQASS---KRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNL 230

  Fly   335 TERQIKIWFQNRRMKLKKEIQAIKELNEQEKQAQAQKAAAAAAAAAAVQGGHLD 388
            |||||||||||||||.||:.:....|.....|:.::......|      ||:|:
Human   231 TERQIKIWFQNRRMKYKKDQKGKGMLTSSGGQSPSRSPVPPGA------GGYLN 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubx	NP_536752.1	Homeobox	299..352	CDD:395001	37/52 (71%)
HOXA3	NP_001371264.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..147		11/74 (15%)
		Antp-type hexapeptide	155..160		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..196		9/44 (20%)
		Homeobox	195..248	CDD:395001	37/52 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..338		8/38 (21%)
		DUF4074	378..441	CDD:404218
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810