Protein Alignment Ubx and TLX1

DIOPT Version :10

• Sequence 1: NP_536752.1
• Gene: Ubx / 42034
• FlyBaseID: FBgn0003944
• Length: 389
• Species: Drosophila melanogaster
• Sequence 2: XP_011538046.1
• Gene: TLX1 / 3195
• HGNCID: 5056
• Length: 342
• Species: Homo sapiens
• Alignment Length: 367
• Identity: 97/367 - (26%)
• Similarity: 136/367 - (37%)
• Gaps: 108/367 - (29%)

  Fly    26 GGHHDQTASAAAAAYRGFPLSLGMSPYANHHLQRTTQDSPYDASITAACNKIYGDGAGAYKQDCL 90
            |.||.....|.       |:|.|:....|         ||.........:::..   |.|...||
Human     5 GPHHLHPGHAE-------PISFGIDQILN---------SPDQGGCMGPASRLQD---GEYGLGCL 50

  Fly    91 NIKADAVNGYKDIWNTGGSNGGGGGGG----GGGGGGAGGTGGAGNANGGNAANANGQNNPAGGM 151
                           .||:...||||.    |.||.||.||||.|           |...||||
Human    51 ---------------VGGAYTYGGGGSAAATGAGGAGAYGTGGPG-----------GPGGPAGG- 88

  Fly   152 PVRPSACTPDSRVGGY---LDTSGGSPVSHRGGSAGGNVSVSGGNGNAGGVQSGVGVAGAGTAWN 213
               ..||:.....|.|   :..:||......|||:||           .|..|..||...    .
Human    89 ---GGACSMGPLTGSYNVNMALAGGPGPGGGGGSSGG-----------AGALSAAGVIRV----P 135

  Fly   214 ANCTISGAAA-------------QTAAASSLHQASNHTFYPWMAIAGECPEDPTKSKIRSDLTQY 265
            |:..::||.|             ...|...::..:..|| |||    |.....||.:....|:.:
Human   136 AHRPLAGAVAHPQPLATGLPTVPSVPAMPGVNNLTGLTF-PWM----ESNRRYTKDRFTVALSPF 195

  Fly   266 GGISTDMGKRYSESLAGSLLPDWLGTNGLRRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAH 330
             .::..:|..|...           |...:::.|.::||.|..||||.||...||....|..:|.
Human   196 -TVTRRIGHPYQNR-----------TPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAK 248

  Fly   331 ALCLTERQIKIWFQNRRMKLKKEIQAIKELNEQEKQAQAQKA 372
            ||.:|:.|:|.||||||.|.:::       ..:|::|:.|:|
Human   249 ALKMTDAQVKTWFQNRRTKWRRQ-------TAEEREAERQQA 283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubx	NP_536752.1	Homeodomain	296..352	CDD:459649	26/55 (47%)
TLX1	XP_011538046.1	Homeodomain	214..270	CDD:459649	26/55 (47%)