DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ubx and GBX2

DIOPT Version :9

Sequence 1:	NP_536752.1	Gene:	Ubx / 42034	FlyBaseID:	FBgn0003944	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_001476.2	Gene:	GBX2 / 2637	HGNCID:	4186	Length:	348	Species:	Homo sapiens

Alignment Length:	230	Identity:	66/230 - (28%)
Similarity:	92/230 - (40%)	Gaps:	43/230 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 GGYLDTSGGSPVSHRGGSAGGNVS----VSGGNGNAGGVQSGVGVAGAGTAWNANCTISGAAAQT 225
            ||:    ..|| .|:..:|....:    ..|||.:...........|.|........::.:||:|
Human   110 GGF----SASP-QHQEAAAARKFAPQPLPGGGNFDKAEALQADAEDGKGFLAKEGSLLAFSAAET 169

  Fly   226 AAASSLHQASNHTFYPWMAIAGECP-----EDPTKSK-----IRSDLT---------QYGGISTD 271
            ..||.:.           |:.|:..     ||..|.|     :.||:.         |......|
Human   170 VQASLVG-----------AVRGQGKDESKVEDDPKGKEESFSLESDVDYSSDDNLTGQAAHKEED 223

  Fly   272 MGKRYSESLAGSLLPDWLGTNGLRRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTE 336
            .|....|:...|.......:.|..||.|..:|..|.||||||||...||:...|.::||||.|:|
Human   224 PGHALEETPPSSGAAGSTTSTGKNRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSE 288

  Fly   337 RQIKIWFQNRRMKLKKEIQAIKELNEQEKQAQAQK 371
            .|:||||||||.|.|:    :|..|...|..:..:
Human   289 VQVKIWFQNRRAKWKR----VKAGNANSKTGEPSR 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubx	NP_536752.1	Homeobox	299..352	CDD:395001	30/52 (58%)
GBX2	NP_001476.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..81
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	111..139		8/32 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..251		15/71 (21%)
		Homeobox	250..303	CDD:306543	30/52 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810