Protein Alignment Ubx and EN1

DIOPT Version :10

• Sequence 1: NP_536752.1
• Gene: Ubx / 42034
• FlyBaseID: FBgn0003944
• Length: 389
• Species: Drosophila melanogaster
• Sequence 2: NP_001417.3
• Gene: EN1 / 2019
• HGNCID: 3342
• Length: 392
• Species: Homo sapiens
• Alignment Length: 259
• Identity: 76/259 - (29%)
• Similarity: 95/259 - (36%)
• Gaps: 58/259 - (22%)

  Fly   124 AGGTGGAGNANGGNAANANGQNNPAGGMPVRPSA----------CTPDSRVGGYLDTSGGSPVSH 178
            |...||||  .||......|| ..||..||.|..          |.||:..|   ...|..|
Human   130 AAARGGAG--GGGRVERDRGQ-TAAGRDPVHPLGTRAPGAASLLCAPDANCG---PPDGSQP--- 185

  Fly   179 RGGSAGGNVSVSGGNGNAGGVQSGVGVAGAGTAWNANCTISGAAAQTAAASSLHQASNHTFYP-- 241
              .:||...| ..||..|....:...||.|..|..|..:.:|.......|.|  ..:..|.||
Human   186 --AAAGAGAS-KAGNPAAAAAAAAAAVAAAAAAAAAKPSDTGGGGSGGGAGS--PGAQGTKYPEH 245

  Fly   242 ------WMAIAGECPEDPTKSK------------IRSDLTQYGGISTDMGKRYSESLAGSLLPDW 288
                  .|..|...|...|.|:            ..||....|..:..:.|:.:|.      .|
Human   246 GNPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTRYSDRPSSGPRTRKLKKKKNEK------ED- 303

  Fly   289 LGTNGLRRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLKK 352
                   :|.|..:|..|...|:.||..|.|:|.:||..:|..|.|.|.||||||||:|.|:||
Human   304 -------KRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQIKIWFQNKRAKIKK 360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubx	NP_536752.1	Homeodomain	296..352	CDD:459649	26/55 (47%)
EN1	NP_001417.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..164		13/34 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..251		6/33 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..306		6/37 (16%)
		Homeodomain	305..360	CDD:459649	26/54 (48%)
		Engrail_1_C_sig	361..391	CDD:431338	76/259 (29%)