Protein Alignment Ubx and Nkx6-1

DIOPT Version :10

• Sequence 1: NP_536752.1
• Gene: Ubx / 42034
• FlyBaseID: FBgn0003944
• Length: 389
• Species: Drosophila melanogaster
• Sequence 2: NP_659204.1
• Gene: Nkx6-1 / 18096
• MGIID: 1206039
• Length: 365
• Species: Mus musculus
• Alignment Length: 298
• Identity: 73/298 - (24%)
• Similarity: 110/298 - (36%)
• Gaps: 88/298 - (29%)

  Fly   127 TGGAGNANGGNAANAN----GQNNP-------AGGM------PVRPSACTPDSRVGGYLDTSGGS 174
            ||...:::..:::::.    |.:||       |||:      |.:.||.||.    |..|.....
Mouse    45 TGPPSSSSSSSSSSSPSPPLGSHNPGGLKPPAAGGLSSLGSPPQQLSAATPH----GINDILSRP 105

  Fly   175 PVSHRGGSAGGNVSVSGGNGNAGGVQSGVGVAGAGTAWNANCTISGAAAQTAAASSLHQASNHTF 239
            .:....|:|..:.|.||.:.::....|....:.|..|        .|||..|||||
Mouse   106 SMPVASGAALPSASPSGSSSSSSSSASATSASAAAAA--------AAAAAAAAASS--------- 153

  Fly   240 YPWMAIAG-------ECPEDPTKSKIRSDLTQYGGISTDMGKRYSESLA---------------- 281
             |...:||       ..|..|..............:.     ||.:.||
Mouse   154 -PAGLLAGLPRFSSLSPPPPPPGLYFSPSAAAVAAVG-----RYPKPLAELPGRTPIFWPGVMQS 212

  Fly   282 --------------GSLLPDWLGTNGLRRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHAL 332
                          ||:|   |..:|.|:..|.|::..|...|||.|....||....|..:|::|
Mouse   213 PPWRDARLACTPHQGSIL---LDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSL 274

  Fly   333 CLTERQIKIWFQNRRMKLKK----EIQAIKELNEQEKQ 366
            .:||.|:|:||||||.|.:|    |:...|:..:.|.:
Mouse   275 GMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETE 312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubx	NP_536752.1	Homeodomain	296..352	CDD:459649	23/55 (42%)
Nkx6-1	NP_659204.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..136		21/94 (22%)
		Repressor domain. /evidence=ECO:0000250	102..269		41/192 (21%)
		Homeodomain	236..294	CDD:459649	24/57 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..365		3/18 (17%)
		Involved in DNA-binding. /evidence=ECO:0000250	307..365		1/6 (17%)