DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ubx and Hoxd3

DIOPT Version :9

Sequence 1:	NP_536752.1	Gene:	Ubx / 42034	FlyBaseID:	FBgn0003944	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_034598.2	Gene:	Hoxd3 / 15434	MGIID:	96207	Length:	433	Species:	Mus musculus

Alignment Length:	392	Identity:	102/392 - (26%)
Similarity:	132/392 - (33%)	Gaps:	133/392 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QASGFYGHPHQATGMAMGSGGHHDQTASAAAAAYRGFPLSLGMSPYANHHLQRTTQDSPYDASIT 71
            |.:.:|.:|    |:..|.|      .|.|...| |:                :|...||..  .
Mouse    18 QKAAYYENP----GLFGGYG------YSKATDTY-GY----------------STPHQPYPP--P 53

  Fly    72 AACNKIYGDGAGAYKQDCLNIKADA-----------VNGYKDIWNTGGSNGGGGGGGGGGGGGAG 125
            ||.|.:..|    |.....:|::.|           :||......||.|.|||||....|
Mouse    54 AAANSLDSD----YPSSACSIQSSAPLRAPAHKGAELNGSCMRPGTGNSQGGGGGNQPPG----- 109

  Fly   126 GTGGAGNANGGNAANANGQNNPAGGMPVRPSACTPDSRVGGYLDTSGGSPVSHRGGSAGGNVSVS 190
                           .|.:..|....|..|....|.|      .|:.||.|..:        ...
Mouse   110 ---------------LNSEQQPPQPPPPPPPTLPPSS------PTNPGSGVPAK--------KTK 145

  Fly   191 GGNGNAGGVQSGVGVAGAGTAWNANCTISGAAAQTAAASSLHQASNHTFYPWMAIAGECPEDPTK 255
            ||                                 .:|||.....:...:|||      .|....
Mouse   146 GG---------------------------------LSASSSSSTISKQIFPWM------KESRQN 171

  Fly   256 SKIRSDLTQYGGISTDMGKRYSESLAGSLLPDWLGTNGLRRRGRQTYTRYQTLELEKEFHTNHYL 320
            ||                ::.|.:.:|....|........:|.|..||..|.:|||||||.|.||
Mouse   172 SK----------------QKNSCATSGENCEDKSPPGPASKRVRTAYTSAQLVELEKEFHFNRYL 220

  Fly   321 TRRRRIEMAHALCLTERQIKIWFQNRRMKLKKEIQAIKELNEQEKQAQAQKAAAAAAAAAAVQGG 385
            .|.||:|||:.|.||||||||||||||||.||:.:|...|:....|:..:......||......|
Mouse   221 CRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKAKGILHSPAGQSPERSPPLGGAAGHVAYSG 285

  Fly   386 HL 387
            .|
Mouse   286 QL 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubx	NP_536752.1	Homeobox	299..352	CDD:395001	37/52 (71%)
Hoxd3	NP_034598.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..198		45/248 (18%)
		Antp-type hexapeptide	161..166		3/10 (30%)
		Homeobox	199..251	CDD:278475	37/51 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..280		4/21 (19%)
		DUF4074	370..431	CDD:290032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810