DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ubx and Hoxb5

DIOPT Version :9

Sequence 1:	NP_536752.1	Gene:	Ubx / 42034	FlyBaseID:	FBgn0003944	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_032294.2	Gene:	Hoxb5 / 15413	MGIID:	96186	Length:	269	Species:	Mus musculus

Alignment Length:	405	Identity:	109/405 - (26%)
Similarity:	139/405 - (34%)	Gaps:	159/405 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNSYFEQA-SGFY--GHPHQATGMAMG---SGGHHDQTASAAAA---AYRGFPLSLGMSPYANHH 56
            |:|||..: ||.|  |..:|......|   ||.:.|..|....:   .|.|..||:..|..::.|
Mouse     1 MSSYFVNSFSGRYPNGPDYQLLNYGSGSSLSGSYRDPAAMHTGSYGYNYNGMDLSVNRSSASSSH 65

  Fly    57 LQRTTQDS---------PYDASITAACNKIYGDGAGAYKQDCLNIKADAVNGYKDIWNTGGSNGG 112
            .....:.|         |.....|::|:.     :......|.|               |.|:|
Mouse    66 FGAVGESSRAFPASAQEPRFRQATSSCSL-----SSPESLPCTN---------------GDSHG- 109

  Fly   113 GGGGGGGGGGGAGGTGGAGNANGGNAANANGQNNPAGGMPVRPSACTPDSRVGGYLDTSGGSPVS 177
                                                    .:|||.:|..:         .:|.|
Mouse   110 ----------------------------------------AKPSASSPSDQ---------ATPAS 125

  Fly   178 HRGGSAG----GNVSVSGGNGNAGGVQSGVGVAGAGTAWNANCTISGAAAQTAAASSLHQASNHT 238
               .||.    ...|.|.....|....|...:|.|..        ...|..|||.    :.....
Mouse   126 ---SSANFTEIDEASASSEPEEAASQLSSPSLARAQP--------EPMATSTAAP----EGQTPQ 175

  Fly   239 FYPWMAIAGECPEDPTKSKIRSDLTQYGGISTDMGKRYSESLAGSLLPDWLGTNGLRRRGRQTYT 303
            .:|||          .|..|..|:|                          |.:|  :|.|..||
Mouse   176 IFPWM----------RKLHISHDMT--------------------------GPDG--KRARTAYT 202

  Fly   304 RYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLKKEIQAIKELNEQEKQAQ 368
            ||||||||||||.|.|||||||||:||||||:||||||||||||||.||:              .
Mouse   203 RYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKD--------------N 253

  Fly   369 AQKAAAAAAAAAAVQ 383
            ..|:.:.|.|.:|.|
Mouse   254 KLKSMSLATAGSAFQ 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubx	NP_536752.1	Homeobox	299..352	CDD:395001	45/52 (87%)
Hoxb5	NP_032294.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..173		26/182 (14%)
		Antp-type hexapeptide	176..181		3/14 (21%)
		Homeobox	198..251	CDD:365835	45/52 (87%)
		PRK07003	<67..>171	CDD:235906	27/188 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45659
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910