DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ubx and Hoxa3

DIOPT Version :9

Sequence 1:	NP_536752.1	Gene:	Ubx / 42034	FlyBaseID:	FBgn0003944	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_034582.1	Gene:	Hoxa3 / 15400	MGIID:	96175	Length:	443	Species:	Mus musculus

Alignment Length:	297	Identity:	87/297 - (29%)
Similarity:	111/297 - (37%)	Gaps:	87/297 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 ANGQNNPAGGMPVRPS-------------ACTPDSRVGGYLDTSGGSPVSHRGGSA-----GGNV 187
            |||....|...|..||             ||:..|..     ::||.|.:|....|     .|..
Mouse    21 ANGFAYNASQQPYAPSAALGTDGVEYHRPACSLQSPA-----SAGGHPKTHELSEACLRTLSGPP 80

  Fly   188 SVSGGNGN------------------------------AGGVQSGVGVAGAGTAWNANCTISGAA 222
            |...|.|.                              |....|.|....:.   |:|.|    .
Mouse    81 SQPPGLGEPPLPPPPPQAAPPAPQPPQPPPQPPAPTPAAPPPPSSVSPPQSA---NSNPT----P 138

  Fly   223 AQTAAASSLHQAS-NHTFYPWMAIAGECPEDPTKSKIRSDLTQYGGISTDMGKRYSESLAGSLLP 286
            |.||.:..|:..: ....:|||..:    ...||.|             ..|....||.||...|
Mouse   139 ASTAKSPLLNSPTVGKQIFPWMKES----RQNTKQK-------------TSGSSSGESCAGDKSP 186

  Fly   287 DWLGTNGLRRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLK 351
            ....::   :|.|..||..|.:|||||||.|.||.|.||:|||:.|.||||||||||||||||.|
Mouse   187 PGQASS---KRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYK 248

  Fly   352 KEIQAIKELNEQEKQAQAQKAAAAAAAAAAVQGGHLD 388
            |:.:....|.....|:.::......|      ||:|:
Mouse   249 KDQKGKGMLTSSGGQSPSRSPVPPGA------GGYLN 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubx	NP_536752.1	Homeobox	299..352	CDD:395001	37/52 (71%)
Hoxa3	NP_034582.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..151		14/83 (17%)
		Antp-type hexapeptide	156..161		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..197		10/53 (19%)
		COG5576	<182..309	CDD:227863	48/107 (45%)
		Homeobox	196..249	CDD:365835	37/52 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	248..354		8/38 (21%)
		DUF4074	378..441	CDD:372548
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810