Protein Alignment Ubx and NKX2-6

DIOPT Version :10

• Sequence 1: NP_536752.1
• Gene: Ubx / 42034
• FlyBaseID: FBgn0003944
• Length: 389
• Species: Drosophila melanogaster
• Sequence 2: NP_001129743.2
• Gene: NKX2-6 / 137814
• HGNCID: 32940
• Length: 301
• Species: Homo sapiens
• Alignment Length: 249
• Identity: 57/249 - (22%)
• Similarity: 74/249 - (29%)
• Gaps: 109/249 - (43%)

  Fly   108 GSNGGGGGGGGGGGGGAGGTGGAGNANGGNAANANGQNNPAGGMPVRPSACTPDSRVGGYLDTSG 172
            ||.....|||||.....|.....|........:|.....|..|:    :|.:|         ..|
Human    52 GSEVHNAGGGGGDRKLDGSEPPGGPCEAVLEMDAERMGEPQPGL----NAASP---------LGG 103

  Fly   173 GSPVSHRG-GSAGGNVSVSGGNGNAGGVQSGVGVAGAGTAWNANCTISGAAAQTAAASSLHQASN 236
            |:.|..|| |::|.  ||.||..
Human   104 GTRVPERGVGNSGD--SVRGGRS------------------------------------------ 124

  Fly   237 HTFYPWMAIAGECPEDPTKSKIRSDLTQYGGISTDMGKRYSESLAGSLLPDWLGTNGLRRRGRQT 301
                          |.|   |.|.                                  ||:.|..
Human   125 --------------EQP---KARQ----------------------------------RRKPRVL 138

  Fly   302 YTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLKKEIQ 355
            :::.|.|.||:.|....||:...|..:|.||.||..|:||||||||.|.|::.|
Human   139 FSQAQVLALERRFKQQRYLSAPEREHLASALQLTSTQVKIWFQNRRYKCKRQRQ 192

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubx	NP_536752.1	Homeodomain	296..352	CDD:459649	25/55 (45%)
NKX2-6	NP_001129743.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..135		31/190 (16%)
		Homeodomain	133..189	CDD:459649	25/55 (45%)