DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ubx and Hoxa1

DIOPT Version :9

Sequence 1:	NP_536752.1	Gene:	Ubx / 42034	FlyBaseID:	FBgn0003944	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_037207.2	Gene:	Hoxa1 / 103690132	RGDID:	11414885	Length:	334	Species:	Rattus norvegicus

Alignment Length:	420	Identity:	99/420 - (23%)
Similarity:	151/420 - (35%)	Gaps:	148/420 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNSYFEQ---ASG--------FYGHPH-----QATGMAMGSGGHHDQTASAAAAAYRGFPLSLGM 49
            |||:.|.   .||        .|...|     |:..::..|.|..|:....     ||..::
  Rat     6 MNSFLEYPILGSGDSGTCSARVYSSDHGITTFQSCAVSANSCGGDDRFLGG-----RGVQIT--- 62

  Fly    50 SPYANHHLQRTTQDSPYDAS-------ITAACNKIYG--DGAGAYKQDCLNIKADAVNGYKDIWN 105
            ||:.:||.....|.:.|..|       ..::|...||  :.:..|....||.:||...||
  Rat    63 SPHHHHHHHHHPQPATYQTSGNLGVSYSHSSCGPSYGAQNFSAPYGPYGLNQEADVSGGY----- 122

  Fly   106 TGGSNGGGGGGGGGGGGGAGGTGGAGNANGGNAANANGQNNPAGGMPVRPSACTPDSRVGGYLDT 170
                                                              ..|.|....|..
  Rat   123 --------------------------------------------------PPCAPAVYSGNL--- 134

  Fly   171 SGGSPV----SHRGGSAGGNVSVSGGNGNAGGVQSGVGVAGAGTA---WNANCTISGAAAQTAAA 228
              .||:    .|..|.|||.|      |:...:....|......|   :|.:.:...|:.|.|..
  Rat   135 --SSPMVQHHHHHQGYAGGTV------GSPQYIHHSYGQEHQSLALATYNNSLSPLHASHQEACR 191

  Fly   229 SSLHQASN--HTFYPWMAIAGECPEDPTKSKIRSDLTQYGGISTDMGKRYSESLAGSLLPDWLGT 291
            |...:.|:  .|| .||.:    ..:|.|:   ..:.:||.:..               |:.:.|
  Rat   192 SPASETSSPAQTF-DWMKV----KRNPPKT---GKVGEYGYVGQ---------------PNAVRT 233

  Fly   292 NGLRRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLKK-EIQ 355
            |         :|..|..|||||||.|.||||.||:|:|.:|.|.|.|:||||||||||.|| |.:
  Rat   234 N---------FTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREKE 289

  Fly   356 AIKEL-------NEQEKQAQAQKAAAAAAA 378
            .:..:       ::::.:..::|::::.:|
  Rat   290 GLLPISPATPPGSDEKTEESSEKSSSSPSA 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubx	NP_536752.1	Homeobox	299..352	CDD:395001	32/52 (62%)
Hoxa1	NP_037207.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..82		6/23 (26%)
		Interaction with OGT. /evidence=ECO:0000250\|UniProtKB:P09022	74..202		33/193 (17%)
		COG5576	175..>285	CDD:227863	49/141 (35%)
		Antp-type hexapeptide	203..208		3/5 (60%)
		Homeobox	232..284	CDD:278475	34/60 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..334		8/40 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910