Protein Alignment modSP and Tmprss6

DIOPT Version :9

• Sequence 1: NP_536776.2
• Gene: modSP / 42032
• FlyBaseID: FBgn0051217
• Length: 628
• Species: Drosophila melanogaster
• Sequence 2: NP_082178.2
• Gene: Tmprss6 / 71753
• MGIID: 1919003
• Length: 811
• Species: Mus musculus
• Alignment Length: 573
• Identity: 119/573 - (20%)
• Similarity: 173/573 - (30%)
• Gaps: 259/573 - (45%)

  Fly    38 SCISQYDVCNGEKNCPDGSDETALTCVSQRQHCTKPYFQCTY-GACVIGTAGCNGVNECADGSDE 101
            |..:|.|.|.||                         |.|:. |.||   ..|:|:.:|.:|.||
Mouse   450 SLYNQSDPCPGE-------------------------FLCSVNGLCV---PACDGIKDCPNGLDE 486

  Fly   102 TRLRCGNEDDIRQHDRRLQGNCKENEFKCPSGICLDKSNFLCDGKDDCADGTGFDESVELCGH-M 165
            ....|           |....|:|:      ..|:.... :||.:.||.:|:  ||  |.|.. :
Mouse   487 RNCVC-----------RAMFQCQED------STCISLPR-VCDRQPDCLNGS--DE--EQCQEGV 529

  Fly   166 ECPAYSFKCGTGGCI-SGSLSCNGENDCYDGSDEAPLLCNTTKKVTTPVVTETPLELLGCPLPLG 229
            .|..::|:|....|: ..:..|:|::||.|||||....|.
Mouse   530 PCGTFTFQCEDRSCVKKPNPECDGQSDCRDGSDEQHCDCG------------------------- 569

  Fly   230 DERPILTGDGSRVLTGPITRGTVRFSCKQGYVLEGEESSYCAKNKWSTSTIPKCVKYCSTAGEFD 294
                 |.|..||::.|.::.             |||
Mouse   570 -----LQGLSSRIVGGTVSS-------------EGE----------------------------- 587

  Fly   295 GYSTKALCTHNGQQVECRKPFHPPGTEVKFVCSTGFKTLSPLPEMRCMKGGYWNRGRQRCEQDCG 359
                                                                |
Mouse   588 ----------------------------------------------------W------------ 588

  Fly   360 QLATPIKQFSSGGYTINNTVVPWHVGLYVWHNEKDYHFQCGGSLLTPDLVITAAHCVYDEGTRLP 424
                                 ||...|.:    :..|. |||:|:....|||||||..::....|
Mouse   589 ---------------------PWQASLQI----RGRHI-CGGALIADRWVITAAHCFQEDSMASP 627

  Fly   425 YSYDTFRVIAAKFYRNYGETTPEEKRRDVRLIEIAPGYKGRTENYYQDLALLTLDEPFELSHVIR 489
            ..:..|   ..|..:|  ...|.|....|..:.:.|.::..:.:|  |:|||.||.|...|..:|
Mouse   628 KLWTVF---LGKMRQN--SRWPGEVSFKVSRLFLHPYHEEDSHDY--DVALLQLDHPVVYSATVR 685

  Fly   490 PICVTFAS-FAEKESVTDDVQGK---FAGW----------NIENKHELQFVPAVSKSNSVCRRNL 540
            |:|:...| |.|        .|:   ..||          |...|.::|.||     ..:|....
Mouse   686 PVCLPARSHFFE--------PGQHCWITGWGAQREGGPVSNTLQKVDVQLVP-----QDLCSEAY 737

  Fly   541 R-DIQADKFCI-FTQGKSLACQGDSGGGFTSELPTNAFSTWNTARHFLFGVIS 591
            | .:.....|. :.:||..||||||||......|        :.|.||.|::|
Mouse   738 RYQVSPRMLCAGYRKGKKDACQGDSGGPLVCREP--------SGRWFLAGLVS 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
modSP	NP_536776.2	LDLa	27..58	CDD:197566	6/19 (32%)
		LDLa	70..101	CDD:197566	9/31 (29%)
		LDLa	123..157	CDD:197566	8/33 (24%)
		LDLa	167..199	CDD:238060	12/32 (38%)
		CCP	<251..284	CDD:153056	3/32 (9%)
		Sushi	309..354	CDD:278512	1/44 (2%)
		Tryp_SPc	371..616	CDD:214473	65/237 (27%)
		Tryp_SPc	371..591	CDD:304450	64/235 (27%)
Tmprss6	NP_082178.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..48
		SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060	13/57 (23%)
		LDLa	495..525	CDD:238060	11/40 (28%)
		Ldl_recept_a	529..566	CDD:278486	13/36 (36%)
		Tryp_SPc	576..806	CDD:214473	71/367 (19%)
		Tryp_SPc	577..809	CDD:238113	70/366 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910