DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment modSP and Masp2

DIOPT Version :9

Sequence 1:NP_536776.2 Gene:modSP / 42032 FlyBaseID:FBgn0051217 Length:628 Species:Drosophila melanogaster
Sequence 2:NP_742040.1 Gene:Masp2 / 64459 RGDID:620214 Length:685 Species:Rattus norvegicus


Alignment Length:648 Identity:137/648 - (21%)
Similarity:209/648 - (32%) Gaps:187/648 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 KPY--FQCTYGACVIGTAGCNGVNECADGSDETRLRCGNEDDIRQHDRRLQG----NCK------ 124
            ||:  |:..|               .|:..||.|...|:......:.....|    :|:      
  Rat   125 KPFTGFEAFY---------------AA
EDVDECRTSLGDSVPCDHYCHNYLGGYYCSCRVGYILH 174

  Fly   125 ENEFKCPSGIC-----LDKSNFLCDGK--------DDCADGTGFDE------------SVELCGH 164
            :|:..| |.:|     ..:|.||...:        ..||.....:|            .||:...
  Rat   175 QNKHTC-SALCSGQVFTGRSGFLSSPEYPQPYPKLSSCAYNIRLEEGFSITLDFVESFDVEMHPE 238

  Fly   165 MECPAYSFKCGTGGCISGSLSCNGENDCYDGSDEAPLLCNTTKKVTTPVVTETPLELLG------ 223
            .:||..|.|..|.         ..|...:.|....|.:...:.|||....|:......|      
  Rat   239 AQCPYDSLKIQTD---------KREYGPFCGKTLPPRIETDSNKVTITFTTDESGNHTGWKIHYT 294

  Fly   224 -----CPLPLGDERPILTGDGSRVLTGPITRGTVRFSCKQGY-VLEGEE-----SSYCAKNKWST 277
                 ||.|....    .|..|.|....:.:.:....||.|: :|:|..     ::.|.|:....
  Rat   295 STAQPCPDPTAPP----NGHISPVQATYVLKDSFSVFCKTGFELLQGSVPLKSFTAVCQKDGSWD 355

  Fly   278 STIPKCVKYCSTAGEFDGYSTKALCTHNGQQVECRKPFHPPGTEVKFV---------------CS 327
            ..||:|                       ..::|..|...|...|.::               |.
  Rat   356 RPIPEC-----------------------SIIDCGPPDDLPNGHVDYITGPEVTTYKAVIQYSCE 397

  Fly   328 TGFKTLSPLPEMRCMKGGYW--NRGRQR---CEQDCGQLATPIKQFSSGGYTINNTVV-----PW 382
            ..|.|:|...:..|...|:|  ::|.:.   |:..||     :...:|||..|.....     ||
  Rat   398 ETFYTMSSNGKYVCEADGFWTSSKGEKSLPVCKPVCG-----LSTHTSGGRIIGGQPAKPGDFPW 457

  Fly   383 HVGLYVWHNEKDYHFQCGGSLLTPDLVITAAHCVYDEGTRLPYSYDTFRVIAAKFYRNYGETTPE 447
            .|.|.       ......|:|:..|.|:||||.||.: |....|.|....|..:...:|.:..||
  Rat   458 QVLLL-------GETTAAGALIHDDWVLTAAHAVYGK-TEAMSSLDIRMGILKRLSPHYTQAWPE 514

  Fly   448 EKRRDVRLIEIAPGYKGRTENYYQDLALLTLDEPFELSHVIRPICVTFASFAEKESVT---DDVQ 509
                   .:.|..||. ....:..|:||:.|.....::..|.|||:     ..||:.:   .|..
  Rat   515 -------AVFIHEGYT-HGAGFDNDIALIKLKNKVTINRNIMPICL-----PRKEAASLMKTDFV 566

  Fly   510 GKFAGWNIENK----HELQFV--PAVSKSNSVCRRNLRDIQADKFCI------FTQGKSLACQGD 562
            |..|||.:..|    ..|.||  |.|...........:.....|..:      ...|...:|:||
  Rat   567 GTVAGWGLTQKGFLARNLMFVDIPIVDHQKCATAYTKQPYPGAKVTVNMLCAGLDAGGKDSCRGD 631

  Fly   563 SGGGFTSELPTNAFSTWNTARHFLFGVIS----NAPNADQCAHSLTVMTNIQHFEDMILNAMN 621
            |||..       .|....|.|.|:.|::|    |...::|..    |.|.:.::...|.|.:|
  Rat   632 SGGAL-------VFLDNETQRWFVGGIVSWGSINCGGSEQYG----VYTKVTNYIPWIENIIN 683

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
modSPNP_536776.2 LDLa 27..58 CDD:197566
LDLa 70..101 CDD:197566 5/30 (17%)
LDLa 123..157 CDD:197566 10/52 (19%)
LDLa 167..199 CDD:238060 7/31 (23%)
CCP <251..284 CDD:153056 9/38 (24%)
Sushi 309..354 CDD:278512 12/64 (19%)
Tryp_SPc 371..616 CDD:214473 66/268 (25%)
Tryp_SPc 371..591 CDD:304450 61/239 (26%)
Masp2NP_742040.1 CUB 19..136 CDD:238001 4/25 (16%)
FXa_inhibition 152..180 CDD:291342 3/27 (11%)
CUB 184..295 CDD:238001 22/119 (18%)
Sushi 300..361 CDD:278512 15/64 (23%)
Sushi 366..429 CDD:278512 12/62 (19%)
Tryp_SPc 443..678 CDD:214473 64/266 (24%)
Tryp_SPc 444..681 CDD:238113 65/268 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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