DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment modSP and Hgfac

DIOPT Version :9

Sequence 1:	NP_536776.2	Gene:	modSP / 42032	FlyBaseID:	FBgn0051217	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_445772.1	Gene:	Hgfac / 58947	RGDID:	70909	Length:	653	Species:	Rattus norvegicus

Alignment Length:	650	Identity:	139/650 - (21%)
Similarity:	202/650 - (31%)	Gaps:	214/650 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 QHCTKPYFQCTYGACVIGTAGCNGVNECADGSDETRLRCGNEDDIRQHDR-RLQGNCKENEF--- 128
            |.|..|:   .||..::        :.|:......|..|..   ...:|| |..|.|.|...
  Rat   103 QPCRFPF---RYGGRML--------HSCSSEGSAYRKWCAT---THNYDRDRAWGYCAEATLPVE 153

  Fly   129 ------KCPSGICLDKSNFLCDGKDDCADGTGFDESVELCGHMECP-AYSFK-CGTGGCISGS-- 183
                  .|.||.||:...  |....|           .:..|..|| |::.| |||..|...:
  Rat   154 GPAVLDPCASGPCLNGGT--CSSTQD-----------HVSYHCACPLAFTGKDCGTEKCFDETRY 205

  Fly   184 -------------------LSC-NGENDCYDGSDEAPLLCNTTKKVTTPVVTETPLELLGCPLP- 227
                               .|| .|:..|.|....|.|........|..::..|...:..|||.
  Rat   206 EYFEVGDHWARVSEGHVEQCSCIEGQARCEDTHHTACLSSPCLNGGTCHLIVGTGTSICACPLGY 270

  Fly   228 -------LGDERPILTGDGSRVLTGPITRGTVRFSC-----------------KQGYVLEGEESS 268
                   :..||..| |:|:. ..|..:......||                 ....:|.....:
  Rat   271 AGRFCNIVPTERCFL-GNGTE-YRGVASTSASGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHA 333

  Fly   269 YCAKNKWSTSTIPKC--VKYCSTAGEFDGYSTKALCTHNGQQVECRKPFHPPGTEVKFVCSTGFK 331
            || :|. .....|.|  ||..:.:.|   |...|.| .:..:|..|.|                :
  Rat   334 YC-RNP-DKDERPWCYVVKDSALSWE---YCRLAAC-ESLARVHSRIP----------------E 376

  Fly   332 TLSPLPEMRCMKGGYWNRGRQRCEQDCG---QLATPIKQFSSGGYTINNTVVPWHVGLYVWHNEK 393
            .|:.|||           ........||   :..|.::....||.:......||...:|:.:.
  Rat   377 VLATLPE-----------STSTARPTCGKRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGNG-- 428

  Fly   394 DYHFQCGGSLLTPDLVITAAHCVYDEGTRLPYSYDTFRVIAAKFYRNYGETTPEEKRRDVRLIEI 458
                .|.|||:....|::||||......|     |:..|:..:.:.|             |..::
  Rat   429 ----FCAGSLVHTCWVVSAAHCFSSSPPR-----DSITVVLGQHFFN-------------RTTDV 471

  Fly   459 APGYKGRTENYY------------QDLALLTLDEPFE----LSHVIRPICVTFASFAEKESVTDD 507
            ...:  ..|.|.            .||.|:.|.:..|    .|..::|||:..|.    .|....
  Rat   472 TQTF--AIEKYVPYTLYSVFNPNDHDLVLIRLKKKGERCAVRSQFVQPICLPEAG----SSFPTG 530

  Fly   508 VQGKFAGW-----NI---ENKHELQFVPAVS----KSNSVCRRNLRDIQADKFCI-FTQGKSLAC 559
            .:.:.|||     |:   .|......||.|:    .|..|..   .||..:..|. :...||.||
  Rat   531 HKCQIAGWGHMDENVSGYSNSLLEALVPLVADHKCSSPEVYG---ADISPNMLCAGYFDCKSDAC 592

  Fly   560 QGDSGGGFTSELPTNAFSTWNTARHFLFGVIS--------NAPNADQCAHSLTVMTNIQHFEDMI 616
            ||||||....|  .|..:       :|:|:||        |.|.         |.|.:.::.|.|
  Rat   593 QGDSGGPLVCE--KNGVA-------YLYGIISWGDGCGRLNKPG---------VYTRVSNYVDWI 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
modSP	NP_536776.2	LDLa	27..58	CDD:197566
		LDLa	70..101	CDD:197566	5/30 (17%)
		LDLa	123..157	CDD:197566	9/42 (21%)
		LDLa	167..199	CDD:238060	13/55 (24%)
		CCP	<251..284	CDD:153056	8/51 (16%)
		Sushi	309..354	CDD:278512	7/44 (16%)
		Tryp_SPc	371..616	CDD:214473	66/281 (23%)
		Tryp_SPc	371..591	CDD:304450	59/248 (24%)
Hgfac	NP_445772.1	FN2	99..145	CDD:128373	12/55 (22%)
		EGF_CA	159..194	CDD:238011	12/47 (26%)
		FN1	197..237	CDD:238018	5/39 (13%)
		EGF	242..274	CDD:278437	6/31 (19%)
		Kringle	283..364	CDD:278480	17/87 (20%)
		Tryp_SPc	405..639	CDD:214473	66/284 (23%)
		Tryp_SPc	406..641	CDD:238113	66/284 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000