DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment modSP and prss12

DIOPT Version :9

Sequence 1:	NP_536776.2	Gene:	modSP / 42032	FlyBaseID:	FBgn0051217	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	XP_001920299.3	Gene:	prss12 / 566809	ZFINID:	ZDB-GENE-090313-45	Length:	818	Species:	Danio rerio

Alignment Length:	841	Identity:	154/841 - (18%)
Similarity:	259/841 - (30%)	Gaps:	327/841 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CALLLKF-RT---IFAAC--------------DSSQ--FECDN------------GSCISQYDVC 46
            |||||.. ||   .|..|              ||::  .:|.|            |..:..:..|
Zfish    12 CALLLMIARTGGSPFTDCVQSKGKAGFYEGSIDSTESGVKCMNWSDVPGVRERYQGKGLGDHTFC 76

  Fly    47 NGEKNCPDGSDETALTCVSQRQHCTKPYFQCTYGACVI--GTAGCNGVNE----------CADGS 99
            ..    |||.........:.|......|..|..|:..:  |.:..:|..|          |::|.
Zfish    77 RN----PDGRIRPWCFFTNNRGRIDWGYCDCKQGSLRLQGGRSKLDGTVEVYLNGVWGTICSNGW 137

  Fly   100 DE-----------------------TRL----------RC-GNEDDIRQHDRRL--QGNCKENEF 128
            |:                       :||          .| |.|||:.|.:|.:  .|.|:..:.
Zfish   138 DDQDAAVVCRQLGQGYRAHARMSPLSRLVVSVVHWQTVGCEGQEDDLLQCNRTVWNGGECENRQA 202

  Fly   129 KCPSGICLDKSNF--------------------------LCDGKDDCADGTGFDESVELCGHMEC 167
            ...|.:.::.|.|                          :||.:.|..|.......:.|.|..:.
Zfish   203 AAVSCMPVETSVFVPVRLSGGPSAYEGRVEVYHAGQWGTVCDDQWDDNDAEVVCRQLGLGGIAKA 267

  Fly   168 --PAYSFKCGTGGCISGSLSCN--------------GENDCYDGSDEAPLLCNTTKKVTTPVV-- 214
              .|| |..|:|......:||.              ||::| |.:::|.:.|.........:|
Zfish   268 WVGAY-FGAGSGRVFLDEVSCTGNELSIEQCPKTAWGEHNC-DHTEDAGVSCVPLTDGAVRLVGG 330

  Fly   215 ------------------------TETPLELLGCPLPLGDERPILTGDGSRVLTGPITRGTVRFS 255
                                    |:|..:::...|.......:..|... :..||:....||.:
Zfish   331 VKGYEGRLEVHYRGQWGTVCDDGWTQTNTQVVCRQLGFRSGESVSAGRFG-IAAGPVLLDDVRCT 394

  Fly   256 CKQGYVLEGEESSYCAKNKW-------------------STSTIPKCVKYCSTAGEFD------- 294
            .|:..|      ::|::..|                   |...:|..:......||.:
Zfish   395 GKEPTV------THCSRRGWFKHDCTHRQDVAIVCSPQCSRHGVPNSLPVRLVGGENEREGRVEI 453

  Fly   295 --GYSTKALC----THNGQQVECRK--------------------PFHPPGTEVKFVCSTGFKTL 333
              |.....:|    |....:|.||:                    |.|....:    |:.|..:|
Zfish   454 LVGGQWGTVCDDGWTDRDAEVVCRQLGYSGLAKARVMAYFGEGEGPIHIDNVK----CTGGEHSL 514

  Fly   334 SPLPEMRCMKGGYWNRGRQRC--EQDCGQLAT-PIKQFSSG---------GYTINNT----VV-- 380
            :.     |:|..:   |...|  .:|.|.:.. .::|.|.|         |..:::|    ::
Zfish   515 TD-----CIKQPF---GTHNCRHSEDAGVICNYGLQQDSPGVKEAVGSMCGLRLSHTRQKRIIGG 571

  Fly   381 --------PWHVGLYVWHNEKDYHFQCGGSLLTPDLVITAAHCV--YDEGTRLPYSYDTFRVIAA 435
                    ||...:.:..::.|....||.:|::...::|:|||.  |...|.|      ::|...
Zfish   572 ENSLRGGWPWQAAVRLRGSQADGRLVCGATLISSCWILTSAHCFKRYGNSTGL------YKVRVG 630

  Fly   436 KFYRNYGETTPEEKRRD--VRLIEIAPGYKGRTENYYQDLALLTLD----------EPFELSHVI 488
                :|....|||...:  |..|.:.|.|...:.:|  |||||.:.          :...||..:
Zfish   631 ----DYHSLVPEEYEEEYAVEKIVLHPRYHADSSDY--DLALLRVSGHRAHRGVTGQCVTLSRSV 689

  Fly   489 RPICVTFASFAEKESVTDDVQGKF-AGW----------------------NIENKHELQFVPAVS 530
            .|.|:.    ..:|.|...:...: .||                      ..|.::..||.
Zfish   690 LPACLP----VRREKVPKGIANCYITGWGDTGRAYSKTLQQASISVLSKRQCEQRYSEQFT---- 746

  Fly   531 KSNSVCRRNLRDIQADKFCIFTQGKSLACQGDSGGGFTSELPTNAFSTWNTARHFLFGVIS 591
             :..:|..:..|.|          :..:|:|||||....|.|:   .:|     .::||.|
Zfish   747 -NRMLCAGSSHDAQ----------RVDSCRGDSGGPLVCERPS---GSW-----VVYGVTS 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
modSP	NP_536776.2	LDLa	27..58	CDD:197566	10/58 (17%)
		LDLa	70..101	CDD:197566	8/42 (19%)
		LDLa	123..157	CDD:197566	8/59 (14%)
		LDLa	167..199	CDD:238060	11/47 (23%)
		CCP	<251..284	CDD:153056	8/51 (16%)
		Sushi	309..354	CDD:278512	11/64 (17%)
		Tryp_SPc	371..616	CDD:214473	57/281 (20%)
		Tryp_SPc	371..591	CDD:304450	56/279 (20%)
prss12	XP_001920299.3	KR	28..105	CDD:294073	13/80 (16%)
		SRCR	113..207	CDD:278931	17/93 (18%)
		SR	218..317	CDD:214555	18/100 (18%)
		SRCR	223..317	CDD:278931	18/95 (19%)
		SR	325..424	CDD:214555	13/105 (12%)
		SRCR	334..424	CDD:278931	12/96 (13%)
		SR	438..538	CDD:214555	19/111 (17%)
		SRCR	443..538	CDD:278931	19/106 (18%)
		Tryp_SPc	567..812	CDD:214473	54/261 (21%)
		Tryp_SPc	568..815	CDD:238113	54/260 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000