DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment modSP and TMPRSS15

DIOPT Version :9

Sequence 1:NP_536776.2 Gene:modSP / 42032 FlyBaseID:FBgn0051217 Length:628 Species:Drosophila melanogaster
Sequence 2:XP_011527956.1 Gene:TMPRSS15 / 5651 HGNCID:9490 Length:1064 Species:Homo sapiens


Alignment Length:678 Identity:156/678 - (23%)
Similarity:225/678 - (33%) Gaps:215/678 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 LKFRTIFAACDS---SQFECDNGSCISQYDVCNG------------------------------- 48
            :||:..|.|..:   |....|:.|.  .|.:|||                               
Human   518 VKFKVAFNAFKNKILSDIALDDISL--TYGICNGSLYPEPTLVPTPPPELPTDCGGPFELWEPNT 580

  Fly    49 ---EKNCPDGSDETALTCV----SQRQHCTKPYFQCTYGACVIGTAGCNGVNECADGSDETRLRC 106
               ..|.|:.....|. ||    :|:....:.:||      .......|.|.|..||.:...|..
Human   581 TFSSTNFPNSYPNLAF-CVWILNAQKGKNIQLHFQ------EFDLENINDVVEIRDGEEADSLLL 638

  Fly   107 ------GNEDDIRQHDRRLQGNCKENEFKCPSGICLDKSNFLCDGKDDCADGTGFDESVELCGHM 165
                  |...|:.....|:......|:.....|.   |:||.          ||:        |:
Human   639 AVYTGPGPVKDVFSTTNRMTVLLITNDVLARGGF---KANFT----------TGY--------HL 682

  Fly   166 ----ECPAYSFKCGTGGCISGSLSCNGENDCYDGSDEAPLLCNTTKKVTTPVVTETPLELLGCPL 226
                .|.|..|:|..|.|:.....|:|...|.||||||                           
Human   683 GIPEPCKADHFQCKNGECVPLVNLCDGHLHCEDGSDEA--------------------------- 720

  Fly   227 PLGDERPILTGDGSRVLTGPI-TRGTVRFSCKQGYVLEGEESSYCAKNKWSTSTIPKCVKYCSTA 290
                       |..|...|.. ..|.|||.      ::....:.||:| |:|. |...|  |...
Human   721 -----------DCVRFFNGTTNNNGLVRFR------IQSIWHTACAEN-WTTQ-ISNDV--CQLL 764

  Fly   291 GEFDGYSTKALCTHNGQQVECRKPFHPPGTEVKF-VCSTGFKTLSPLPEMRCMKGGYWNRGRQRC 354
            |...|.|:|.:...:|            |..||. ....|...|:  |..:|::....   |.:|
Human   765 GLGSGNSSKPIFPTDG------------GPFVKLNTAPDGHLILT--PSQQCLQDSLI---RLQC 812

  Fly   355 -EQDCGQ--LATPIKQFSSGGYTINNTVVPWHVGLYVWHNEKDY--HFQCGGSLLTPDLVITAAH 414
             .:.||:  .|..|.....||........||.||||       |  ...||.||::.|.:::|||
Human   813 NHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLY-------YGGRLLCGASLVSSDWLVSAAH 870

  Fly   415 CVYDEGTRLPYSYDTFRVIAAKFYRNYGETTPEEKRRDVRLIEIAPGYKGRTENYYQDLALLTLD 479
            |||  |..|..|..| .::......|.  |:|:...|.:..|.|.|.|..|.::  .|:|::.|:
Human   871 CVY--GRNLEPSKWT-AILGLHMKSNL--TSPQTVPRLIDEIVINPHYNRRRKD--NDIAMMHLE 928

  Fly   480 EPFELSHVIRPICVTFASFAEKESVTDDVQGKFAGW----------NIENKHELQFVPAVSKSNS 534
            .....:..|:|||:.    .|.:..........|||          ||..:.:   ||.:  ||.
Human   929 FKVNYTDYIQPICLP----EENQVFPPGRNCSIAGWGTVVYQGTTANILQEAD---VPLL--SNE 984

  Fly   535 VCRRNLRD--IQADKFCI-FTQGKSLACQGDSGGGFTSELPTNAFSTWNTARHFLFGVIS----- 591
            .|::.:.:  |..:..|. :.:|...:|||||||....:         ...|.||.||.|     
Human   985 RCQQQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQ---------ENNRWFLAGVTSFGYKC 1040

  Fly   592 ---NAPNADQCAHSLTVMTNIQHFEDMI 616
               |.|.         |...:..|.:.|
Human  1041 ALPNRPG---------VYARVSRFTEWI 1059

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
modSPNP_536776.2 LDLa 27..58 CDD:197566 9/67 (13%)
LDLa 70..101 CDD:197566 7/30 (23%)
LDLa 123..157 CDD:197566 7/33 (21%)
LDLa 167..199 CDD:238060 13/31 (42%)
CCP <251..284 CDD:153056 9/32 (28%)
Sushi 309..354 CDD:278512 8/45 (18%)
Tryp_SPc 371..616 CDD:214473 71/267 (27%)
Tryp_SPc 371..591 CDD:304450 66/234 (28%)
TMPRSS15XP_011527956.1 SEA 53..195 CDD:214554
LDLa 229..263 CDD:238060
CUB 270..376 CDD:278839
MAM 387..547 CDD:214533 8/30 (27%)
MAM 392..547 CDD:99706 8/30 (27%)
CUB 569..676 CDD:278839 20/116 (17%)
LDLa 688..722 CDD:238060 15/71 (21%)
SR 723..816 CDD:214555 28/119 (24%)
Tryp_SPc 829..1059 CDD:214473 71/270 (26%)
Tryp_SPc 830..1061 CDD:238113 72/271 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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