DRSC/TRiP Functional Genomics Resources

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Protein Alignment modSP and MASP1

DIOPT Version :9

Sequence 1:NP_536776.2 Gene:modSP / 42032 FlyBaseID:FBgn0051217 Length:628 Species:Drosophila melanogaster
Sequence 2:XP_011511291.1 Gene:MASP1 / 5648 HGNCID:6901 Length:735 Species:Homo sapiens


Alignment Length:655 Identity:138/655 - (21%)
Similarity:224/655 - (34%) Gaps:205/655 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    92 VNECADGSDETRLRCGNEDD---------------IRQHDRRLQGNCKENEFKCPSGI------- 134
            |:||.:..|| .|.|.:...               :...:|..:..|.:|.|...:|:       
Human   147 VDECKEREDE-ELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 210

  Fly   135 --------CLDKSNFLCDGKDDCADGTGFDESVELCGHME--CPAYSFKCGTGGCISGSLSCNGE 189
                    ||    :..:.::.......|::..::..|.|  ||....|...|..:.|.. | ||
Human   211 NPYPKSSECL----YTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPKVLGPF-C-GE 269

  Fly   190 NDCYDGSDEAPLLCNTTKKVTTPVVTETPLELL-----------GCPL---PLGDERPILTGDGS 240
                              |...|:.|::...|:           |..|   ..|:|.|.|.    
Human   270 ------------------KAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQ---- 312

  Fly   241 RVLTGPITRGTVR-------------FSCKQGY-VLEG--EESSY---CAKNKWSTSTIPKC-VK 285
                 |...|.:.             .||..|| ||:.  |..::   |.|:...::.||.| :.
Human   313 -----PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTCKIV 372

  Fly   286 YCSTAGEFD----GYSTK-ALCTHNGQ-QVECRKPFHPPGTEVKFVCSTGFKTLSPLPEMRCMKG 344
            .|...||.:    .:||: .|.|:..: :..|::|::.....     :||..|        |...
Human   373 DCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNN-----NTGIYT--------CSAQ 424

  Fly   345 GYW-----NRGRQRCEQDCGQ----LATPIKQFSSGGYTINNTVVPWHVGLYVWHNEK---DYHF 397
            |.|     .|....|..:|||    |.:.:|:. .||......:.||...:.|....:   |..|
Human   425 GVWMNKVLGRSLPTCLPECGQPSRSLPSLVKRI-IGGRNAEPGLFPWQALIVVEDTSRVPNDKWF 488

  Fly   398 QCGGSLLTPDLVITAAHCVYD---EGTRLPYSYDTFRVIAAKFYRNYGETTPEEKRRDVR----- 454
            . .|:||:...::||||.:..   :.|.:|.|.:...|...              ..|||     
Human   489 G-SGALLSASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLG--------------LHDVRDKSGA 538

  Fly   455 ------LIEIAPGYKGRTENYYQDLALLTLDEPFELSHVIRPICVTFASFAEKESVTDDVQGKFA 513
                  .:.:.|.:  ..:||..|:||:.|.||..|...:.|:|:   ...|.|.....:.|..|
Human   539 VNSSAARVVLHPDF--NIQNYNHDIALVQLQEPVPLGPHVMPVCL---PRLEPEGPAPHMLGLVA 598

  Fly   514 GWNIENKH---------------------ELQFVP-AVSKSNSVCRRNLRDIQADKFCI-FTQGK 555
            ||.|.|.:                     :|..|| |..|::...|.....:..:.||. :.:|.
Human   599 GWGISNPNVTVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYESRSGNYSVTENMFCAGYYEGG 663

  Fly   556 SLACQGDSGGGFT--SELPTNAFSTWNTARHFLFGVIS-NAPNADQCAHSLT--VMTNIQHFEDM 615
            ...|.|||||.|.  .:|         :.|..:.|::| ..|  ::|.....  |.|.:.::.|.
Human   664 KDTCLGDSGGAFVIFDDL---------SQRWVVQGLVSWGGP--EECGSKQVYGVYTKVSNYVDW 717

  Fly   616 ILNAM 620
            :...|
Human   718 VWEQM 722

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
modSPNP_536776.2 LDLa 27..58 CDD:197566
LDLa 70..101 CDD:197566 3/8 (38%)
LDLa 123..157 CDD:197566 7/48 (15%)
LDLa 167..199 CDD:238060 8/31 (26%)
CCP <251..284 CDD:153056 12/52 (23%)
Sushi 309..354 CDD:278512 9/49 (18%)
Tryp_SPc 371..616 CDD:214473 66/289 (23%)
Tryp_SPc 371..591 CDD:304450 60/261 (23%)
MASP1XP_011511291.1 CUB 35..144 CDD:238001
FXa_inhibition 160..188 CDD:291342 2/27 (7%)
CUB 192..301 CDD:278839 23/132 (17%)
Sushi 308..369 CDD:278512 15/69 (22%)
CCP 374..439 CDD:153056 16/77 (21%)
Tryp_SPc 456..718 CDD:214473 66/293 (23%)
Tryp_SPc 457..718 CDD:238113 66/292 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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