DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment modSP and PROC

DIOPT Version :9

Sequence 1:	NP_536776.2	Gene:	modSP / 42032	FlyBaseID:	FBgn0051217	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	XP_024308770.1	Gene:	PROC / 5624	HGNCID:	9451	Length:	576	Species:	Homo sapiens

Alignment Length:	633	Identity:	137/633 - (21%)
Similarity:	210/633 - (33%)	Gaps:	225/633 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 CTYGACVIGTAGCNGVNECADGSDETRLRCGNEDDIRQ-HDRRLQ----GNCKENEFKC---PSG 133
            |.||  :..|.||:|               |...:::. ||..||    ..|..::..|   |.|
Human    60 CGYG--LTRTPGCHG---------------GRTANLQYLHDPPLQVPVPPECGSSQASCCSWPPG 107

  Fly   134 -------------------------------ICLDKSNFLCDGKDDCADGTGFDESVELCGH--- 164
                                           .|:::   :||          |:|:.|:..:
Human   108 EFPAHQLLLVLRIRKRANSFLEELRHSSLERECIEE---ICD----------FEEAKEIFQNVDD 159

  Fly   165 ------------------MECPAYSFKCGTGGCIS--GSLSCNGENDCYDGSDEAPLLCNTTKKV 209
                              :|.|..|..||.|.||.  ||.||    ||..|.:..  .|...:
Human   160 TLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC----DCRSGWEGR--FCQRGE-- 216

  Fly   210 TTPVVTETPLELLGCPLPLGDERPILTGDGSRVLTGP-ITRGTVRFSCKQGYVLEGEESSYCAKN 273
                                .||.:|.|.|:.:  || ..|||               |:.|.:
Human   217 --------------------GERWMLAGGGAGL--GPGWGRGT---------------STSCPR- 243

  Fly   274 KWSTSTIPKCVKYCSTAGEFDGYSTKALCTHNG-QQVECRKPFHPPGTE-----------VKFVC 326
                ..:|..|.:.:.:.:..|      |||.. ::|..|:....||.:           |||.|
Human   244 ----PPLPAEVSFLNCSLDNGG------CTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVKFPC 298

  Fly   327 STGFKTLSPLPEMRCMKGGYWNRGRQRCEQDCGQLATPIKQFSSGGYTINNTVVPWHVGLYVWHN 391
            ...:|.:              .:.|...::|.......:......|........||.|.|.
Human   299 GRPWKRM--------------EKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLL---- 345

  Fly   392 EKDYHFQCGGSLLTPDLVITAAHCVYDEGTRLPY---SYDTFRVIAAKFYRNYGETTPEEKRRDV 453
            :......||..|:.|..|:|||||: ||..:|..   .||..|      :..:      |...|:
Human   346 DSKKKLACGAVLIHPSWVLTAAHCM-DESKKLLVRLGEYDLRR------WEKW------ELDLDI 397

  Fly   454 RLIEIAPGY-KGRTENYYQDLALLTLDEPFELSHVIRPICVTFASFAEKESVTDDVQGKFAGWNI 517
            :.:.:.|.| |..|:|   |:|||.|.:|..||..|.|||:..:..||:|......:....||..
Human   398 KEVFVHPNYSKSTTDN---DIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGY 459

  Fly   518 ENKHE----------LQFVPAVSKSNSVCRRNLRD-IQADKFCIFTQG-KSLACQGDSGGGFTSE 570
            .:..|          |.|:......::.|...:.: :..:..|....| :..||:|||||...:.
Human   460 HSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVAS 524

  Fly   571 LPTNAFSTWNTARHFLFGVISNAPNADQCA--HSLTVMTNIQHFEDMI 616
            .    ..||     ||.|::|   ..:.|.  |:..|.|.:..:.|.|
Human   525 F----HGTW-----FLVGLVS---WGEGCGLLHNYGVYTKVSRYLDWI 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
modSP	NP_536776.2	LDLa	27..58	CDD:197566
		LDLa	70..101	CDD:197566	7/23 (30%)
		LDLa	123..157	CDD:197566	8/67 (12%)
		LDLa	167..199	CDD:238060	14/33 (42%)
		CCP	<251..284	CDD:153056	4/32 (13%)
		Sushi	309..354	CDD:278512	10/55 (18%)
		Tryp_SPc	371..616	CDD:214473	69/262 (26%)
		Tryp_SPc	371..591	CDD:304450	63/235 (27%)
PROC	XP_024308770.1	GLA	117..168	CDD:214503	6/63 (10%)
		EGF_CA	182..213	CDD:238011	13/36 (36%)
		FXa_inhibition	255..290	CDD:317114	8/40 (20%)
		Tryp_SPc	328..563	CDD:238113	70/265 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910