DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment modSP and snk

DIOPT Version :9

Sequence 1:	NP_536776.2	Gene:	modSP / 42032	FlyBaseID:	FBgn0051217	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001097766.1	Gene:	snk / 41607	FlyBaseID:	FBgn0003450	Length:	435	Species:	Drosophila melanogaster

Alignment Length:	469	Identity:	117/469 - (24%)
Similarity:	174/469 - (37%)	Gaps:	119/469 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 DEAPLLCNTTKKVTTPVV-TETPLELLGCPL---PLGDERPILT-GDGSRVLTGPITRGTVRFSC 256
            |...::...|.|.|.|.| .|.|:..:|..:   ...||...|. ||.:.|.|.
  Fly    29 DALEIINYQTTKYTIPEVWKEQPVATIGEDVDDQDTEDEESYLKFGDDAEVRTS----------- 82

  Fly   257 KQGYVLEG-EESSYCAKNKWSTSTIPKCVKYCSTA-------GEFDGYSTKA-LCTH-NGQQVEC 311
                |.|| .|.::|.::....|      .||..|       .|:..:.|:. :||| |...|.|
  Fly    83 ----VSEGLHEGAFCRRSFDGRS------GYCILAYQCLHVIREYRVHGTRIDICTHRNNVPVIC 137

  Fly   312 RKPFHPPGTEVKFVCSTGFKTL--SPLPEMRCMKGGYWNRGRQRCEQD------CGQLATPIKQF 368
                          |....|.:  ..:...:|.:   :|...:|....      .|:...|....
  Fly   138 --------------CPLADKHVLAQRISATKCQE---YNAAARRLHLTDTGRTFSGKQCVPSVPL 185

  Fly   369 SSGGYTINNTVVPWHVGLYVW-----HNEKDYHFQCGGSLLTPDLVITAAHCVYDEGTRLPYSYD 428
            ..||....:.:.| |:....|     ..::|..:.|||:|::...|:|||||. ..|::.|   |
  Fly   186 IVGGTPTRHGLFP-HMAALGWTQGSGSKDQDIKWGCGGALVSELYVLTAAHCA-TSGSKPP---D 245

  Fly   429 TFRVIAAKFYRNYGETTPEEKRRDVRLIEIAPGYKGRTENYYQDLALLTLDEPFELSHVIRPICV 493
            ..|:.|    |...||:..::...:.:|.:.|.|  |:..||.|:|||.|....:.|..:||.|:
  Fly   246 MVRLGA----RQLNETSATQQDIKILIIVLHPKY--RSSAYYHDIALLKLTRRVKFSEQVRPACL 304

  Fly   494 TFASFAEKESVTDDVQGKFAGW----------NIENKHELQFVPAVSKSNSVC-------RRNLR 541
            ......:..:|.      .|||          |...:.:|..||.::     |       ||..|
  Fly   305 WQLPELQIPTVV------AAGWGRTEFLGAKSNALRQVDLDVVPQMT-----CKQIYRKERRLPR 358

  Fly   542 DIQADKFCI-FTQGKSLACQGDSGGGFTSELPTN---AFSTWNTARHFLFGVISNAPNADQCAHS 602
            .|...:||. :..|....|||||||...:.||..   ||....|:    ||....||||.
  Fly   359 GIIEGQFCAGYLPGGRDTCQGDSGGPIHALLPEYNCVAFVVGITS----FGKFCAAPNAP----- 414

  Fly   603 LTVMTNIQHFEDMI 616
             .|.|.:..:.|.|
  Fly   415 -GVYTRLYSYLDWI 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
modSP	NP_536776.2	LDLa	27..58	CDD:197566
		LDLa	70..101	CDD:197566
		LDLa	123..157	CDD:197566
		LDLa	167..199	CDD:238060	1/1 (100%)
		CCP	<251..284	CDD:153056	6/33 (18%)
		Sushi	309..354	CDD:278512	6/46 (13%)
		Tryp_SPc	371..616	CDD:214473	76/270 (28%)
		Tryp_SPc	371..591	CDD:304450	69/245 (28%)
snk	NP_001097766.1	CLIP	93..139	CDD:197829	13/65 (20%)
		Tryp_SPc	186..430	CDD:238113	77/274 (28%)
		Tryp_SPc	186..427	CDD:214473	76/272 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437634
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24260
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940