DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment modSP and Pamr1

DIOPT Version :9

Sequence 1:	NP_536776.2	Gene:	modSP / 42032	FlyBaseID:	FBgn0051217	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	XP_038960854.1	Gene:	Pamr1 / 311252	RGDID:	1308745	Length:	814	Species:	Rattus norvegicus

Alignment Length:	809	Identity:	176/809 - (21%)
Similarity:	265/809 - (32%)	Gaps:	287/809 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQLISFLSNPLFFCALLL------KFRTIFAACDSSQFECDNGSCISQYD----VCNGEKN---- 51
            |:|..:....|.|..|||      ::..|..||..:::......| .:||    :|.|:|.
  Rat    95 MELDRWAQLGLAFLQLLLISSLPREYTVINEACPGAEWNIMCREC-CEYDQIECICPGKKEVVGY 158

  Fly    52 ---CPDGSDETALTCVSQRQHCTKPYFQ----CTYGA--------------CVIGTAGCNGVNEC 95
               |....|....:|:. ...||  .|:    |..|:              |....||..| .:|
  Rat   159 TIPCCRNEDNECDSCLI-HPGCT--IFENCKSCRNGSWGGTLDDFYVKGFYCAECRAGWYG-GDC 219

  Fly    96 ADGSDETRLRCG-----NEDDIRQHDRRLQGNCKENEFKCPSGICLD--------KSNFLC---- 143
                    :|||     ::..|......|..:|:......| |..:.        :.:::|
  Rat   220 --------MRCGQVLRASKGQILLESYPLNAHCEWTIHARP-GFIIQLRFSMLSLEFDYMCQYDY 275

  Fly   144 ------DGKDD------C--------------------ADGT-GFD------ESVELCGHMEC-- 167
                  |..|.      |                    :||: .||      |.:..|....|
  Rat   276 VEVRDGDNSDSPLIKRLCGNERPAPIRSTGSSLHVLFHSDGSKNFDGFHAAFEEITACSSSPCFH 340

  Fly   168 -------PAYSFKCGTGGCISGSLSCNGEN-----DCYDGSDEAPLLCNTTKKVTTPVVTETPLE 220
                   ...||||   .|::|......||     :|.|..  .|:  |..||:|
  Rat   341 DGTCILDTTGSFKC---ACLAGYTGPRCENLLEERNCSDLG--GPV--NGYKKIT---------- 388

  Fly   221 LLGCPLPLGDERPILTGDGSRVLTGPITRGTVRFSCKQGYVLEGEESSYCAKN-KWSTSTIPKCV 284
              |.| .|.:||.:..|.            .|.|.|...|||.|.|...|.:| :||... |.|:
  Rat   389 --GGP-GLLNERHVKIGT------------VVSFFCNGSYVLSGNEKRTCQQNGEWSGKQ-PVCM 437

  Fly   285 KYCSTAGEFDGYSTKALCTHNGQQVECRK-PFH---------------------------PPG-- 319
            |.|......|....:.|    ..||:.|: |.|                           |||
  Rat   438 KACREPKISDLVRRRVL----SMQVQSRETPLHQLYSTAFSKQKLQDASTKKPALPFGDLPPGYQ 498

  Fly   320 ---TEVKFVCSTGFKTLSPLPEMRCMKGGYWNRGRQRCEQDCGQL---ATPIKQFSSGGYTINNT 378
               |:|::.|.:.|..........|::.|.|:.....|...||::   |:|..|         .|
  Rat   499 HLHTQVQYECISPFYHRLGSSRRTCLRTGKWSGRAPSCIPICGKIESVASPKTQ---------GT 554

  Fly   379 VVPWHVGLY--------------VWHNEKDYHFQCGGSLLTPDLVITAAHCVYDEGTRLPYSYDT 429
            ..||...:|              .|      ...|.|:|:....|:.|||||.:.|.........
  Rat   555 RWPWQAAIYRRTSGVHDGGLHKGAW------FLVCSGALVNERTVVVAAHCVTELGKVTIIKTAD 613

  Fly   430 FRVIAAKFYRNYGETTPEEKRRDVRL--IEIAPGYKGRTENYYQDLALLTLDEPFELSHVIRPIC 492
            .:|:..||||:  :...|:..:::|:  |.:.|.|.....:  .|:|:|.|.:...:|..::|||
  Rat   614 LKVVLGKFYRD--DDRDEKTIQNLRISAIILHPNYDPILLD--TDIAVLKLLDKARISTRVQPIC 674

  Fly   493 VTFASFAEKESVTDDVQGKF-------AGWNI---------------------------ENKHEL 523
            :         :.|.|:...|       |||||                           |.:||.
  Rat   675 L---------ATTRDLSASFEESHITVAGWNILADVRSPGFKNDTLHYGMVKVVDSMLCEEQHED 730

  Fly   524 QFVPAVSKSNSVCRRNLRDIQADKFCIFTQGKSLACQGDSGGGFTSELPTNAFSTWNTARHFLFG 588
            ..:|.....|..|        |:|   .....|..|..::||......|..|.|   ..|..|.|
  Rat   731 HGIPVSVTDNMFC--------ANK---DPSTPSNICTAETGGIAALSFPGRASS---EPRWHLVG 781

  Fly   589 VISNAPNADQCAHSL-TVMTNIQHFEDMI 616
            ::|.:.: ..|::|| |..|.:..|:|.|
  Rat   782 LVSWSYD-KTCSNSLSTAFTKVLPFKDWI 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
modSP	NP_536776.2	LDLa	27..58	CDD:197566	8/41 (20%)
		LDLa	70..101	CDD:197566	10/48 (21%)
		LDLa	123..157	CDD:197566	11/84 (13%)
		LDLa	167..199	CDD:238060	11/45 (24%)
		CCP	<251..284	CDD:153056	13/33 (39%)
		Sushi	309..354	CDD:278512	14/77 (18%)
		Tryp_SPc	371..616	CDD:214473	67/295 (23%)
		Tryp_SPc	371..591	CDD:304450	59/269 (22%)
Pamr1	XP_038960854.1	CUB	222..328	CDD:238001	15/106 (14%)
		EGF_CA	333..366	CDD:238011	8/35 (23%)
		CCP	374..436	CDD:153056	26/91 (29%)
		CCP	<502..537	CDD:153056	7/34 (21%)
		Tryp_SPc	555..812	CDD:238113	67/289 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140743at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920