DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment modSP and Tmprss7

DIOPT Version :9

Sequence 1:	NP_536776.2	Gene:	modSP / 42032	FlyBaseID:	FBgn0051217	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001099352.2	Gene:	Tmprss7 / 288118	RGDID:	1304655	Length:	829	Species:	Rattus norvegicus

Alignment Length:	681	Identity:	148/681 - (21%)
Similarity:	233/681 - (34%)	Gaps:	248/681 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LISFLS-NPLFFCAL-------LLKFRTIFAACDSSQFECDNGSCISQYDVCNGEKNCP------ 53
            |:||:| |.|....|       |...|..|......  :|:|...:.:.:...|:.:.|
  Rat   314 LMSFVSTNNLMLVTLKSPYVRRLAGIRAYFEVIPEQ--KCENTILVKEINSFEGKISSPYYPSYY 376

  Fly    54 ------DGSDETALTC--VSQRQHCTKPYFQCTYGACVIGTAGCN----GVNECADGSDETRLRC 106
                  :.:.:|:|:.  ::.:.|        .|........||.    .:||        .:.|
  Rat   377 PPKCKCNWTFQTSLSTLGIALKFH--------NYSITKKSMKGCEHGWWEINE--------HMYC 425

  Fly   107 GNEDDIRQHDRRLQGNCKENEFKCPS---GICLDKSNFLCDGKDDCADGTGFDESVELCGHMECP 168
            |:..|            .|..|:.||   .|.|..|:.|.| |....:...::.|      ..||
  Rat   426 GSYMD------------HETIFRVPSPLVHIQLQCSSRLSD-KPLLVEYGSYNIS------QPCP 471

  Fly   169 AYSFKCGTGGCISGSLSCNGENDCYDGSDEAPLLCNTTKKVTTPVVTETPLELLGCPLPLGDERP 233
            |.||:|.:|.|:..:..|:|.|||:|.|||  |.|.|.|.              .|...:..:..
  Rat   472 AGSFRCSSGLCVPQAQRCDGVNDCFDESDE--LFCVTAKP--------------ACNTSIFRQHG 520

  Fly   234 ILTGDGSRVLTGPITRGTVRFSCKQGYVLEGEESSYCAKNKWSTSTIPKC---VKYCSTAGEFDG 295
            .|..||.:             .|:     :|::...|.::...|:...||   :.:.....:.||
  Rat   521 PLVCDGFQ-------------DCE-----DGQDEQNCTRSIPCTNRTFKCGNDICFRKQNAQCDG 567

  Fly   296 YSTKALCTHNGQQVECRKPFHPPGTEVKFVCSTGFKTLSPLPEMRCMKGGYWNRGRQRCEQDCG- 359
            .            |:|     |..::                                 |:.||
  Rat   568 I------------VDC-----PDRSD---------------------------------EEGCGC 582

  Fly   360 QLATPIKQFSSGGYTINNTVVPWHVGLYVWHNEKDYHF----QCGGSLLTPDLVITAAHCVYDEG 420
            ..::|......||........||.|.|         ||    .||.|:::.:.:::||||.:  |
  Rat   583 SRSSPFLHRVVGGSDSQEGTWPWQVSL---------HFVGSAHCGASVISREWLLSAAHCFH--G 636

  Fly   421 TRL----PYSYDTFRVIA--AKFYRNYGETTPEEKRRDVRLIEIAPGYKGRTENYYQDLALLTLD 479
            .||    |::......:.  |||      .:|      ||.|.:...|..:|.:|  |:|||.|.
  Rat   637 NRLSDPTPWTAHLGMYVQGNAKF------VSP------VRRIVVHEYYNSQTFDY--DIALLQLS 687

  Fly   480 --EPFELSHVIRPICV----TFASFAEKESVTDDVQGKFAGWNIENKHELQFVPAVSKSNSVCRR 538
              .|..|..:|:|||:    ......||..||        ||.  .:||     |.||.:.:.::
  Rat   688 IAWPETLRQLIQPICIPPVGQRVRSGEKCWVT--------GWG--RRHE-----ADSKGSPILQQ 737

  Fly   539 NLRDIQADKFCIFT--------------QGKSLACQGDSGGGFTSELPTNAFSTWNTARHFLFGV 589
            ...::.....|:.|              .|||.||:|||||..:....::  ..|     .|.|:
  Rat   738 AEVELIDQTVCVSTYGIITSRMLCAGVMSGKSDACKGDSGGPLSCRRKSD--GKW-----ILTGI 795

  Fly   590 IS--------NAPNADQCAHSLTVMTNIQHF 612
            :|        |.|.         |.|.:.:|
  Rat   796 VSWGYGCGRPNFPG---------VYTRVSNF 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
modSP	NP_536776.2	LDLa	27..58	CDD:197566	4/42 (10%)
		LDLa	70..101	CDD:197566	5/34 (15%)
		LDLa	123..157	CDD:197566	10/36 (28%)
		LDLa	167..199	CDD:238060	16/31 (52%)
		CCP	<251..284	CDD:153056	6/35 (17%)
		Sushi	309..354	CDD:278512	3/44 (7%)
		Tryp_SPc	371..616	CDD:214473	72/280 (26%)
		Tryp_SPc	371..591	CDD:304450	66/249 (27%)
Tmprss7	NP_001099352.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..49
		SEA	94..190	CDD:279699
		CUB	<257..345	CDD:238001	10/30 (33%)
		LDLa	470..504	CDD:238060	18/35 (51%)
		LDLa	545..580	CDD:238060	9/84 (11%)
		Tryp_SPc	591..821	CDD:214473	72/283 (25%)
		Tryp_SPc	592..823	CDD:238113	72/282 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000