DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment modSP and SEZ6L2

DIOPT Version :9

Sequence 1:	NP_536776.2	Gene:	modSP / 42032	FlyBaseID:	FBgn0051217	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001230261.1	Gene:	SEZ6L2 / 26470	HGNCID:	30844	Length:	923	Species:	Homo sapiens

Alignment Length:	252	Identity:	58/252 - (23%)
Similarity:	90/252 - (35%)	Gaps:	68/252 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 SFKCGTGGCISGS--LSCNGENDCYDGS-DEAPLLCNTTKKVTTPVVTETPLELLGCPLPLGDER 232
            :::|..|..:.||  |:|.     :|.| ..||..|   :|:.|            |    .|..
Human   669 TYQCEPGYELLGSDILTCQ-----WDLSWSAAPPAC---QKIMT------------C----ADPG 709

  Fly   233 PILTGDGSRVLTGPITRGTVRFSCKQGYVLEGEESSYCAKN-----KWSTSTIPKC-VKY--CST 289
            .|..|..:....|......|::.|..||.|||.....|...     ||| ..:||| :||  |..
Human   710 EIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWS-DRVPKCALKYEPCLN 773

  Fly   290 AG-EFDGYSTKALCTHNGQQVECRKPFHPPGTEVKFVCSTGFKTLSPLPEMRCMKG--GYWNRGR 351
            .| ..:||.|  |..|:.|          .|..::|.|..||:.:..: .:.|:.|  ..|....
Human   774 PGVPENGYQT--LYKHHYQ----------AGESLRFFCYEGFELIGEV-TITCVPGHPSQWTSQP 825

  Fly   352 QRC-----------EQDCGQLATPIKQFSSGGYTIN-----NTVVPWHVGLYVWHNE 392
            ..|           :.:..|...|.:|...|...:.     ..|:....|:|:::.:
Human   826 PLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTK 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
modSP	NP_536776.2	LDLa	27..58	CDD:197566
		LDLa	70..101	CDD:197566
		LDLa	123..157	CDD:197566
		LDLa	167..199	CDD:238060	8/30 (27%)
		CCP	<251..284	CDD:153056	14/38 (37%)
		Sushi	309..354	CDD:278512	8/46 (17%)
		Tryp_SPc	371..616	CDD:214473	4/27 (15%)
		Tryp_SPc	371..591	CDD:304450	4/27 (15%)
SEZ6L2	NP_001230261.1	O-glycosylated at one site	41..48
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..152
		CUB	173..285	CDD:238001
		CCP	290..345	CDD:214478
		CUB	349..>417	CDD:238001
		Sushi	464..523	CDD:278512
		CUB	527..617	CDD:238001
		CCP	644..700	CDD:153056	11/38 (29%)
		CCP	705..764	CDD:214478	17/63 (27%)
		CCP	771..829	CDD:153056	16/70 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000