DRSC/TRiP Functional Genomics Resources

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Protein Alignment modSP and SEZ6L

DIOPT Version :9

Sequence 1:NP_536776.2 Gene:modSP / 42032 FlyBaseID:FBgn0051217 Length:628 Species:Drosophila melanogaster
Sequence 2:NP_066938.2 Gene:SEZ6L / 23544 HGNCID:10763 Length:1024 Species:Homo sapiens


Alignment Length:514 Identity:105/514 - (20%)
Similarity:163/514 - (31%) Gaps:159/514 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 QFECDNGSCISQYDVCNGEKNCPDGSDETALTCVSQRQHCTKPYFQCTYGACVIGTAGCNGVNEC 95
            :|.||.|..:.|              ....:.|::.|.    ||:..|...|   .|.|.|....
Human   591 EFTCDPGHSLEQ--------------GPAIIECINVRD----PYWNDTEPLC
---RAMCGGELSA 634

  Fly    96 ADG-----------------------SDETR-------LRCGNEDDIRQHD---------RRLQG 121
            ..|                       .:|.|       |...|.|.:..:|         .:..|
Human   635 VAGVVLSPNWPEPYVEGEDCIWKIHVGEEKRIFLDIQFLNLSNSDILTIYDGDEVMPHILGQYLG 699

  Fly   122 NCKENEF------------KCPSGICLDKS-----NFL-CDGKDDCADGTGFDESVELCGHMEC- 167
            |....:.            ..|:|:...|.     |:: ....|.|:|........:...|.|. 
Human   700 NSGPQKLYSSTPDLTIQFHSDPAGLIFGKGQGFIMNYIEVSRNDSCSDLPEIQNGWKTTSHTELV 764

  Fly   168 --PAYSFKCGTGGCISGSLSCNGENDCYDGSDEAPLLCNTTKKVTTPVVTETPLELLGCPLPLGD 230
              ...:::|..|..|.||.:...:.|....||  |..|......|.|...:....|:..|:    
Human   765 RGARITYQCDPGYDIVGSDTLTCQWDLSWSSD--PPFCEKIMYCTDPGEVDHSTRLISDPV---- 823

  Fly   231 ERPILTGDGSRVLTGPITRGTVRFSCKQGYVLEGEESSYCAKNK-----WSTSTIPKCVKYCSTA 290
               :|.|.            |::::|..|:||||.....|...:     | ||.:|.||...|.|
Human   824 ---LLVGT------------TIQYTCNPGFVLEGSSLLTCYSRETGTPIW-TSRLPHCVSEESLA 872

  Fly   291 GEFDGYSTKALCTHNGQQVECRKPFHPPGTEVKFVCSTGFKTLSPLPEMRCMKG--GYWNRGRQR 353
            .:..|      ...||.|: ..|..:.||..:.|:|..||:.:..: .:||:.|  .:||.....
Human   873 CDNPG------LPENGYQI-LYKRLYLPGESLTFMCYEGFELMGEV-TIRCILGQPSHWNGPLPV 929

  Fly   354 CE--QDCGQLATPIKQFSS-----GGYTINNTVVPWHVGLYVWHNEKDYHFQCGGSLLTPDLVIT 411
            |:  ||..:.|..:.:.::     ||    |..:...:.:.:.            |||.....|.
Human   930 CKVNQDSFEHALEVAEAAAETSLEGG----NMALAIFIPVLII------------SLLLGGAYIY 978

  Fly   412 AAHCVYDEGTRLPYSYDTFRVIAAKFYRNYGETTPEEKRRDVRLIEIAPGYK-GRTENY 469
            ...|.|....|||..|.          ..|.:.|.|.:..:       |.|: |.|..|
Human   979 ITRCRYYSNLRLPLMYS----------HPYSQITVETEFDN-------PIYETGETREY 1020

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
modSPNP_536776.2 LDLa 27..58 CDD:197566 5/26 (19%)
LDLa 70..101 CDD:197566 8/53 (15%)
LDLa 123..157 CDD:197566 7/51 (14%)
LDLa 167..199 CDD:238060 8/34 (24%)
CCP <251..284 CDD:153056 12/37 (32%)
Sushi 309..354 CDD:278512 12/46 (26%)
Tryp_SPc 371..616 CDD:214473 21/100 (21%)
Tryp_SPc 371..591 CDD:304450 21/100 (21%)
SEZ6LNP_066938.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 33..77
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 108..184
O-glycosylated at one site 147..161
O-glycosylated at one site 176..180
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 212..234
CUB 281..388 CDD:238001
CCP 393..448 CDD:214478
CUB 452..561 CDD:238001
Sushi 567..624 CDD:278512 10/50 (20%)
CUB 628..736 CDD:238001 14/107 (13%)
CCP 745..801 CDD:153056 13/57 (23%)
CCP 806..865 CDD:214478 18/78 (23%)
CCP 873..931 CDD:153056 16/65 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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