DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment modSP and Sez6l2

DIOPT Version :9

Sequence 1:	NP_536776.2	Gene:	modSP / 42032	FlyBaseID:	FBgn0051217	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	XP_030098390.1	Gene:	Sez6l2 / 233878	MGIID:	2385295	Length:	930	Species:	Mus musculus

Alignment Length:	303	Identity:	65/303 - (21%)
Similarity:	99/303 - (32%)	Gaps:	118/303 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 SFKCGTGGCISGS--LSCNGENDCYDGS-DEAPLLCNTTKKVTTPVVTETPLELLGCPLPLGDER 232
            :::|..|..:.||  |:|.     :|.| ..||..|   :|:.|            |..|
Mouse   669 TYQCEPGYELLGSDILTCQ-----WDLSWSAAPPAC---QKIMT------------CADP----- 708

  Fly   233 PILTGDGSRVLTGPITRG-------------TVRFSCKQGYVLEGEESSYCAKN-----KWSTST 279
                        |.||.|             .|::.|..||.|||.....|...     ||| ..
Mouse   709 ------------GEITNGHRTASDAGFPVGSHVQYRCLPGYSLEGAAVLTCYSRDTGTPKWS-DR 760

  Fly   280 IPKC-VKY--CSTAG-EFDGYSTKALCTHNGQQVECRKPFHPPGTEVKFVCSTGFKTLSPLPEMR 340
            :||| :||  |...| ..:||.|  |..|:.|          .|..::|.|..||:.:..: .:.
Mouse   761 VPKCALKYEPCLNPGVPENGYQT--LYKHHYQ----------AGESLRFFCYEGFELIGEV-TIT 812

  Fly   341 CMKG--GYWNRGRQRC-----------EQDCGQLATPIKQFSSGGYTIN-----NTVVPWHVGLY 387
            |:.|  ..|......|           :.:..|...|.:|...|...:.     ..|:...:|:|
Mouse   813 CVPGHPSQWTSQPPLCKVAYEELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGIGVY 877

  Fly   388 VWHN---------------------EKDYH---FQCGGSLLTP 406
            :::.                     |.|:.   ::.|.||..|
Mouse   878 IYYTKLQGKSLFGFSGSHSYSPITVESDFSNPLYEAGVSLSPP 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
modSP	NP_536776.2	LDLa	27..58	CDD:197566
		LDLa	70..101	CDD:197566
		LDLa	123..157	CDD:197566
		LDLa	167..199	CDD:238060	8/30 (27%)
		CCP	<251..284	CDD:153056	14/38 (37%)
		Sushi	309..354	CDD:278512	8/46 (17%)
		Tryp_SPc	371..616	CDD:214473	10/65 (15%)
		Tryp_SPc	371..591	CDD:304450	10/65 (15%)
Sez6l2	XP_030098390.1	CUB	173..285	CDD:238001
		CCP	290..345	CDD:153056
		CUB	349..>417	CDD:238001
		Sushi	466..523	CDD:365861
		CUB	527..617	CDD:238001
		PHA02927	<665..828	CDD:222943	51/209 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000