DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment modSP and C1s

DIOPT Version :9

Sequence 1:	NP_536776.2	Gene:	modSP / 42032	FlyBaseID:	FBgn0051217	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_620255.2	Gene:	C1s / 192262	RGDID:	619983	Length:	694	Species:	Rattus norvegicus

Alignment Length:	641	Identity:	142/641 - (22%)
Similarity:	214/641 - (33%)	Gaps:	199/641 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 VNECADGSDETRLRCGNEDDIRQHDRRLQGNCKENEF------KCPSGICLDKSNFLCDGKDDCA 150
            ||||.|.:|   :.|.:             .|  |.|      .||      ...||.|....|.
  Rat   138 VNECTDFTD---VPCSH-------------FC--NNFIGGYFCSCP------PEYFLHDDMRTCG 178

  Fly   151 DGTGFDESVELCGHMECPAY------SFKC---------------------------GTGGCISG 182
            .....|....|.|.:..|.|      :.:|                           ..|.| ..
  Rat   179 VNCSGDVFTALIGEIASPNYPNPYPENSRCEYQIRLQEGFRLVLTIRREDFDVEPADSEGNC-HD 242

  Fly   183 SLSCNGEND-----CYDGSDEAPLLCNTTKKVTTPVVTET---------PLELLGCPLPLGDE-- 231
            ||:...:|.     |.:|. ..||...|... |..:|.:|         .|...|.|:|...|
  Rat   243 SLTFAAKNQQFGPYCGNGF-PGPLTIKTQSN-TLDIVFQTDLTGQNKGWKLRYHGDPIPCPKEIS 305

  Fly   232 -RPILTGDGSRVLTGPITRGTVRFSCKQGY-VLEGEESSYCAKNKWSTSTIPKCVKYCSTAGEFD 294
             ..|...:.::.    :.:..|:.:|..|: |:||        |..|||.
  Rat   306 ANSIWEPEKAKY----VFKDVVKITCVDGFEVVEG--------NVGSTSF--------------- 343

  Fly   295 GYSTKALCTHNGQ----QVECR-------------KPFHPP----GTEVKFVCSTGFKTLSPLP- 337
             |||   |..|||    ::||:             |...|.    |:.:.:.|...:..:....
  Rat   344 -YST---CQSNGQWSNSRLECQPVDCGVPEPIENGKVEDPEDTVFGSVIHYTCEEPYYYMEQEEG 404

  Fly   338 -EMRCMKGGYWNRGR-----QRCEQDCGQLATPIK--QFSSGGYTINNTVVPWHVGLYVWHNEKD 394
             |..|...|.|...:     .:|...||....|.|  |...|||:......||.|
  Rat   405 GEYHCAANGSWVNDQLGVELPKCIPVCGVPTEPFKVQQRIFGGYSTKIQSFPWQV---------- 459

  Fly   395 YHFQC---GGSLLTPDLVITAAHCVYDEGTRLPYSYDTFRVIAAKFYRNYGETTPEEKRRDVRLI 456
             :|:.   ||:|:....|:||||.|  ||...|..|....::..:..||......|      |:|
  Rat   460 -YFESPRGGGALIDEYWVLTAAHVV--EGNSDPVMYVGSTLLKIERLRNAQRLITE------RVI 515

  Fly   457 EIAPGYKGRTE-----NYYQDLALLTLDEPFELSHVIRPICVTFASFAEKESVTDDVQGKFAGW- 515
             |.|.:|...:     |:..|:||:.|.:|.::...:.|||:...|.....|..|  .|..:||
  Rat   516 -IHPSWKQEDDLNTRTNFDNDIALVQLKDPVKMGPTVAPICLPETSSDYNPSEGD--LGLISGWG 577

  Fly   516 NIENK-------------HELQFVPAVSKSNSVCRRNLRDIQADKFCIFTQGKSLACQGDSGGGF 567
            ..||:             ..|:....|...|...|.|......:..|...:|.. :|:|||||.|
  Rat   578 RTENRTNVIQLRGAKLPITSLEKCQQVKVENPKARSNDYVFTDNMICAGEKGVD-SCEGDSGGAF 641

  Fly   568 TSELPTNAFSTWNTARHFLFGVISNAPNADQCAHSLTVMTNIQHFEDMILNAMNRS 623
            ...:|     .....:.::.|::|   ...:|. :..:.|.::::.|.||..|..:
  Rat   642 ALPVP-----NVKDPKFYVAGLVS---WGKKCG-TYGIYTKVKNYVDWILKTMQEN 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
modSP	NP_536776.2	LDLa	27..58	CDD:197566
		LDLa	70..101	CDD:197566	5/8 (63%)
		LDLa	123..157	CDD:197566	9/39 (23%)
		LDLa	167..199	CDD:238060	10/69 (14%)
		CCP	<251..284	CDD:153056	10/33 (30%)
		Sushi	309..354	CDD:278512	10/68 (15%)
		Tryp_SPc	371..616	CDD:214473	65/266 (24%)
		Tryp_SPc	371..591	CDD:304450	61/241 (25%)
C1s	NP_620255.2	CUB	24..135	CDD:238001
		FXa_inhibition	149..177	CDD:405372	9/48 (19%)
		CUB	181..293	CDD:395345	20/114 (18%)
		CCP	300..361	CDD:153056	20/91 (22%)
		CCP	365..428	CDD:153056	8/62 (13%)
		Tryp_SPc	443..681	CDD:214473	65/269 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000