DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment modSP and Hp

DIOPT Version :9

Sequence 1:	NP_536776.2	Gene:	modSP / 42032	FlyBaseID:	FBgn0051217	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_059066.1	Gene:	Hp / 15439	MGIID:	96211	Length:	347	Species:	Mus musculus

Alignment Length:	446	Identity:	77/446 - (17%)
Similarity:	123/446 - (27%)	Gaps:	195/446 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 NDCYDGSDEAPLLCNTTKKVTTPVVTETPLELLGCPLPLGDERPILTGDGSRVLTGPITRGTVRF 254
            ||..|..|::                        ||.|            ..:..|.:.. .||:
Mouse    23 NDAMDFEDDS------------------------CPKP------------PEIANGYVEH-LVRY 50

  Fly   255 SCKQGYVLEGEESSYCAKN---KWSTSTIPKCVKYCSTAGEFDGYSTKALCTHNGQQVECRKPFH 316
            .|:|.|.|..|.......|   :| .:|:         |||
Mouse    51 RCRQFYRLRAEGDGVYTLNDEKQW-VNTV---------AGE------------------------ 81

  Fly   317 PPGTEVKFVCSTGFKTLSPLPEMRCMKGGYWNRGRQRCEQDCGQLATPIKQFSS--GGYTINNTV 379
                              .|||               ||..||:...|:.|...  ||.......
Mouse    82 ------------------KLPE---------------CEAVCGKPKHPVDQVQRIIGGSMDAKGS 113

  Fly   380 VPWHVGLYVWHNEKDYHFQCGGSLLTPDLVITAAHCVYDEGTRLPYSYDTFRVIAAKFYRNYGET 444
            .||...:...|.     ...|.:|::...::|.                     |...:.|:.||
Mouse   114 FPWQAKMISRHG-----LTTGATLISDQWLLTT---------------------AKNLFLNHSET 152

  Fly   445 TPEEKRRDV-----------RLIEIA-----PGYKGRTENYYQDLALLTLDEPFELSHVIRPICV 493
            .   ..:|:           :|:||.     |.:.      ..|:.|:.|.:...::..:.|||:
Mouse   153 A---SAKDITPTLTLYVGKNQLVEIEKVVLHPNHS------VVDIGLIKLKQRVLVTERVMPICL 208

  Fly   494 TFASFAEKESVTDDVQGKFAGW----NIENKHELQFV--PAVSKSNSVC---------RRNLRD- 542
                 ..|:.:.....|..:||    |......|::|  |...:...|.         ::||..
Mouse   209 -----PSKDYIAPGRVGYVSGWGRNANFRFTDRLKYVMLPVADQDKCVVHYENSTVPEKKNLTSP 268

  Fly   543 ------IQADKFCI-FTQGKSLACQGDSGGGFTSELPTNAFSTWNTARHFLFGVIS 591
                  :....||. .|:.:...|.||:|..|.  :......||..|     |::|
Mouse   269 VGVQPILNEHTFCAGLTKYQEDTCYGDAGSAFA--IHDMEEDTWYAA-----GILS 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
modSP	NP_536776.2	LDLa	27..58	CDD:197566
		LDLa	70..101	CDD:197566
		LDLa	123..157	CDD:197566
		LDLa	167..199	CDD:238060	4/8 (50%)
		CCP	<251..284	CDD:153056	10/35 (29%)
		Sushi	309..354	CDD:278512	3/44 (7%)
		Tryp_SPc	371..616	CDD:214473	47/260 (18%)
		Tryp_SPc	371..591	CDD:304450	46/258 (18%)
Hp	NP_059066.1	Sushi	33..86	CDD:278512	20/132 (15%)
		Tryp_SPc	102..340	CDD:214473	47/263 (18%)
		Tryp_SPc	103..343	CDD:238113	47/262 (18%)
		Interaction with CD163. /evidence=ECO:0000250	259..264		0/4 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000