DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment modSP and SEZ6

DIOPT Version :9

Sequence 1:	NP_536776.2	Gene:	modSP / 42032	FlyBaseID:	FBgn0051217	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	XP_011522617.1	Gene:	SEZ6 / 124925	HGNCID:	15955	Length:	1073	Species:	Homo sapiens

Alignment Length:	420	Identity:	82/420 - (19%)
Similarity:	115/420 - (27%)	Gaps:	188/420 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 QFECDNG----------SCISQYD------------VCNGEKNCPDGSDETALTCVSQRQHCTKP 73
            :|.||.|          .|:..:|            ||:||.....|        |....:..:|
Human   556 EFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRAVCSGEITDSAG--------VVLSPNWPEP 612

  Fly    74 YFQ---CTYGACV-----------IGTAGCNGVNECADGSDETRLRCGNEDDIRQH--------D 116
            |.:   |.:|..|           :...|...|....||.|.|....|.....|.|        |
Human   613 YGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMAD 677

  Fly   117 RRLQ--------------------------GNCKE-----NEFKCPSGICLDKSNFLCDGKDDCA 150
            ..:|                          ..|.|     |.:|.||             :.:..
Human   678 VTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPS-------------QPELV 729

  Fly   151 DGTGFDESVELCGHMECPAYSFKCGTGGCISGSL---------------SCNGENDCYDGSDEAP 200
            .||               ..:::|..|..:.||.               ||.....|:|..|
Human   730 HGT---------------VVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQRVTSCHDPGD--- 776

  Fly   201 LLCNTTKKVTTPVVTETPLELLGCP-LPLGDERPILTGDGSRVLTGPITRGTVRFSCKQGYVLEG 264
                          .|....|:..| .|:|                    .||::.|.||:||.|
Human   777 --------------VEHSRRLISSPKFPVG--------------------ATVQYICDQGFVLMG 807

  Fly   265 EESSYC-----AKNKWSTSTIPKC----VKYCSTAGEFDGYSTKALCTHNGQQVECRKPFHPPGT 320
            .....|     ...||| ...|||    :|.|      .|.|    ...||.: ...|..||.|.
Human   808 SSILTCHDRQAGSPKWS-DRAPKCLLEQLKPC------HGLS----APENGAR-SPEKQLHPAGA 860

  Fly   321 EVKFVCSTGFKTLSPLPEMRCMKG--GYWN 348
            .:.|.|:.|: .|.....::|:.|  .:|:
Human   861 TIHFSCAPGY-VLKGQASIKCVPGHPSHWS 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
modSP	NP_536776.2	LDLa	27..58	CDD:197566	11/48 (23%)
		LDLa	70..101	CDD:197566	9/44 (20%)
		LDLa	123..157	CDD:197566	8/38 (21%)
		LDLa	167..199	CDD:238060	9/46 (20%)
		CCP	<251..284	CDD:153056	15/41 (37%)
		Sushi	309..354	CDD:278512	11/42 (26%)
		Tryp_SPc	371..616	CDD:214473
		Tryp_SPc	371..591	CDD:304450
SEZ6	XP_011522617.1	MCPVI	<71..147	CDD:281051
		CUB	244..352	CDD:294042
		CCP	357..413	CDD:153056
		CUB	416..526	CDD:238001
		Sushi	532..589	CDD:278512	6/32 (19%)
		CUB	593..702	CDD:238001	21/116 (18%)
		CCP	710..766	CDD:153056	13/83 (16%)
		CCP	771..830	CDD:214478	21/96 (22%)
		CCP	838..896	CDD:153056	16/64 (25%)
		PepSY_TM	<927..>972	CDD:281863
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000