DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment modSP and CSMD2

DIOPT Version :9

Sequence 1:NP_536776.2 Gene:modSP / 42032 FlyBaseID:FBgn0051217 Length:628 Species:Drosophila melanogaster
Sequence 2:NP_001268885.1 Gene:CSMD2 / 114784 HGNCID:19290 Length:3631 Species:Homo sapiens


Alignment Length:519 Identity:116/519 - (22%)
Similarity:168/519 - (32%) Gaps:178/519 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 TKPYFQCTYGACVIGTAGCNGVNECAD-GSDETR--------LRCGNEDDIR-QHDR-RLQGNCK 124
            ||..:.|:.|..:  .||.....||.| |....|        :.|.:...|. :|.| ||   ..
Human  2549 TKAMYSCSEGYHL--QAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRL---IF 2608

  Fly   125 ENEFKCPSGICLDKSNFLCD----------------GKDDCADGTGFDESVELCGHMECPAYSFK 173
            |.:::..:.:.|     :||                ||....|.|.....:. ||.:..|....:
Human  2609 ETQYQFQAQLML-----ICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIIS-CGELPIPPNGHR 2667

  Fly   174 CGTGGCISGS--LSCNG-------------ENDCYDGSDEAPLLCNTTK------KVTTPVVTET 217
            .||......:  .|||.             .|..:.|| |...|...||      |:...|::..
Human  2668 IGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGS-EVRCLATQTKLHSIFYKLLFDVLSSP 2731

  Fly   218 PLELLG-CPLPLGDERPILTGD---------GSRV--------LTG------------------- 245
            .|...| |    |...||:.|.         ||.|        |.|                   
Human  2732 SLTKAGHC----GTPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFC 2792

  Fly   246 -PITRG-------------------TVRFSCKQGYVLEGEESSYC-AKNKWSTSTIPKCVKYCST 289
             |||.|                   .|:|.|..||:.||...|.| |..:|| ..:|.|      
Human  2793 VPITCGHPGNPVNGLTQGNQFNLNDVVKFVCNPGYMAEGAARSQCLASGQWS-DMLPTC------ 2850

  Fly   290 AGEFDGYSTKAL-CTHNGQQVECRKPFHPP-------GTEVKFVCSTGFKTLSPLPEMRCMKGGY 346
                     :.: ||..|.|....:..|..       ||.|.:.|:.||..|. .|.:.|...|.
Human  2851 ---------RIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGFYLLG-TPVLSCQGDGT 2905

  Fly   347 WNRGRQRC-EQDCGQLAT-PIKQFSSGGYTINNTVVPWHVG--LYVWHNEK----DYHF-----Q 398
            |:|.|.:| ...||...: |..|.|...||:...|....:|  ..|.::.:    |.|:     .
Human  2906 WDRPRPQCLLVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPH 2970

  Fly   399 CGGSLL----TPDLVITAAHCV-----YDEGTRLPYSYDTFRVIAAKFYR------NYGETTPE 447
            |.|:.:    .|.:   .||.:     :|.||.:.:|.:...|:.....|      ::..:.||
Human  2971 CSGTSVGVCGDPGI---PAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPE 3031

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
modSPNP_536776.2 LDLa 27..58 CDD:197566
LDLa 70..101 CDD:197566 10/30 (33%)
LDLa 123..157 CDD:197566 8/49 (16%)
LDLa 167..199 CDD:238060 9/46 (20%)
CCP <251..284 CDD:153056 13/33 (39%)
Sushi 309..354 CDD:278512 14/51 (27%)
Tryp_SPc 371..616 CDD:214473 20/103 (19%)
Tryp_SPc 371..591 CDD:304450 20/103 (19%)
CSMD2NP_001268885.1 CUB 66..173 CDD:238001
CCP 179..236 CDD:214478
CUB 242..345 CDD:238001
CCP 383..441 CDD:153056
CUB 445..553 CDD:278839
CCP 561..615 CDD:153056
CUB 618..725 CDD:238001
CCP 731..789 CDD:153056
CUB 792..899 CDD:238001
CCP 907..961 CDD:153056
CUB 964..1072 CDD:238001
CCP 1079..1135 CDD:153056
CUB 1138..1245 CDD:238001
CCP 1251..1308 CDD:153056
CUB 1311..1419 CDD:238001
CCP 1425..1482 CDD:153056
CUB 1485..1590 CDD:278839
CCP <1595..>1687 CDD:332582
CUB 1659..1766 CDD:238001
CCP 1775..1833 CDD:153056
CUB 1836..1941 CDD:238001
CCP 1949..2005 CDD:153056
CUB 2008..2115 CDD:238001
Sushi 2121..2176 CDD:306569
CUB 2180..2286 CDD:238001
Sushi 2292..2349 CDD:306569
CUB 2357..2463 CDD:238001
CCP <2486..2642 CDD:332582 22/102 (22%)
CCP 2609..2850 CDD:332582 54/252 (21%)
CCP 2792..3032 CDD:332582 62/260 (24%)
Sushi 3037..3091 CDD:306569
CCP 3091..3330 CDD:332582
CCP 3290..>3389 CDD:332582
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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