DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment modSP and St14

DIOPT Version :9

Sequence 1:	NP_536776.2	Gene:	modSP / 42032	FlyBaseID:	FBgn0051217	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_446087.1	Gene:	St14 / 114093	RGDID:	69288	Length:	855	Species:	Rattus norvegicus

Alignment Length:	638	Identity:	159/638 - (24%)
Similarity:	214/638 - (33%)	Gaps:	241/638 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GSCISQYDVCNGEKNCPD------GSDETALTCVSQRQH-------------------CTKPYFQ 76
            |||...|...||||.|.:      .|:.:.:|......|                   | ...|.
  Rat   395 GSCTKDYVEINGEKFCGERSQFVVSSNSSKITVHFHSDHSYTDTGFLAEYLSYDSNDPC-PGMFM 458

  Fly    77 CTYGACVIGTAGCNGVNECADGSDETRLRCGNEDDIRQHDRRLQGNCKENEFKCPSGICLDKSNF 141
            |..|.|:.....|:|..:|.|.|||...||.                ..::|.|.:..|  |..|
  Rat   459 CKTGRCIRKDLRCDGWADCPDYSDERHCRCN----------------ATHQFMCKNQFC--KPLF 505

  Fly   142 -LCDGKDDCADGTGFDESVELCGHMECPAYSFKCGTGGCISGSLSCNGENDCYDGSDEAPLLCNT 205
             :||..:||.||:  ||  |.|   .|||.||||..|.|:..|..|||::||.||||||.  |:.
  Rat   506 WVCDSVNDCGDGS--DE--EGC---SCPAGSFKCSNGKCLPQSQQCNGKDDCGDGSDEAS--CDN 561

  Fly   206 TKKVTTPVVTETPLELLGCPLPLGDERPILTGDGSRVLTGPITRGTVRFSCKQGYVLEGEESSYC 270
            ...|:             |                       |:.|.|  |:.|..|
  Rat   562 VNAVS-------------C-----------------------TKYTYR--CQNGLCL-------- 580

  Fly   271 AKNKWSTSTIPKCVKYCSTAGEFDGYSTKALCTHNGQQVECRKPFHPPGTEVKFVCSTGFKTLSP 335
              ||.:    |:|          ||   |..|:....:..|
  Rat   581 --NKGN----PEC----------DG---KKDCSDGSDEKNC------------------------ 602

  Fly   336 LPEMRCMKGGYWNRGRQRCEQDCGQLATPIKQFSS-----GGYTINNTVVPWHVGLYVWHNEKDY 395
                                 |||     ::.|:.     ||...:....||.|.|   |.....
  Rat   603 ---------------------DCG-----LRSFTKQARVVGGTNADEGEWPWQVSL---HALGQG 638

  Fly   396 HFQCGGSLLTPDLVITAAHCVYDEGTRLPYSYDTFRVIAAKFYRNYGETTPEEKRRDVRLIEIAP 460
            |. ||.||::||.:::||||..|| |...||..|..............:....:...::.|...|
  Rat   639 HL-CGASLISPDWLVSAAHCFQDE-TIFKYSDHTMWTAFLGLLDQSKRSASGVQEHKLKRIITHP 701

  Fly   461 GYKGRTENYYQDLALLTLDEPFELSHVIRPICVTFASFAEKESVTDDVQ----GK---FAGWN-- 516
            .:...|.:|  |:|||.|::|.|.|.|:||||           :.|:..    ||   ..||.
  Rat   702 SFNDFTFDY--DIALLELEKPAEYSTVVRPIC-----------LPDNTHVFPAGKAIWVTGWGHT 753

  Fly   517 --------IENKHELQFVPAVSKSNSVCRRNL-RDIQADKFCI-FTQGKSLACQGDSGGGFTSEL 571
                    |..|.|::.:     :.:.|...| :.|.....|: |..|...:|||||||..:
  Rat   754 KEGGTGALILQKGEIRVI-----NQTTCEELLPQQITPRMMCVGFLSGGVDSCQGDSGGPLS--- 810

  Fly   572 PTNAFSTWNTARHFLFGVIS--------NAPNADQCAHSLTVMTNIQHFEDMI 616
                 |.....|.|..||:|        |.|.         |.|.|....|.|
  Rat   811 -----SVEKDGRIFQAGVVSWGEGCAQRNKPG---------VYTRIPEVRDWI 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
modSP	NP_536776.2	LDLa	27..58	CDD:197566	10/26 (38%)
		LDLa	70..101	CDD:197566	10/30 (33%)
		LDLa	123..157	CDD:197566	11/34 (32%)
		LDLa	167..199	CDD:238060	19/31 (61%)
		CCP	<251..284	CDD:153056	8/32 (25%)
		Sushi	309..354	CDD:278512	1/44 (2%)
		Tryp_SPc	371..616	CDD:214473	74/271 (27%)
		Tryp_SPc	371..591	CDD:304450	67/238 (28%)
St14	NP_446087.1	SEA	88..178	CDD:396113
		CUB	214..332	CDD:238001
		CUB	340..444	CDD:238001	12/48 (25%)
		LDLa	454..486	CDD:238060	11/31 (35%)
		LDLa	492..523	CDD:238060	14/36 (39%)
		LDLa	525..559	CDD:238060	21/35 (60%)
		LDLa	567..602	CDD:238060	15/86 (17%)
		Tryp_SPc	615..852	CDD:238113	75/275 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910