DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment modSP and MASP2

DIOPT Version :9

Sequence 1:NP_536776.2 Gene:modSP / 42032 FlyBaseID:FBgn0051217 Length:628 Species:Drosophila melanogaster
Sequence 2:NP_006601.2 Gene:MASP2 / 10747 HGNCID:6902 Length:686 Species:Homo sapiens


Alignment Length:657 Identity:138/657 - (21%)
Similarity:212/657 - (32%) Gaps:210/657 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 KPY--FQCTYGACVIGTAGCNGVNEC--ADGSDETRLRCGNEDDIRQHDRRLQGNCKENEFKCPS 132
            ||:  |:..|.|        ..::||  |.|...|   |    |...|:......|     .|.:
Human   125 KPFTGFEAFY
AA--------EDIDECQVAPGEAPT---C----DHHCHNHLGGFYC-----SCRA 169

  Fly   133 GICLDKS----NFLCDGK---------------------DDCA------DG----TGFDESVELC 162
            |..|.::    :.||.|:                     ..|.      :|    ..|.||.::.
Human   170 GYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVE 234

  Fly   163 GHME--CPAYSFKCGTGGCISGSLSCNGENDCYDGSDEAPLLCNTT---------KKVTTPVVTE 216
            .|.|  ||....|..|                 |..:..| .|..|         ..||...||:
Human   235 THPETLCPYDFLKIQT-----------------DREEHGP-FCGKTLPHRIETKSNTVTITFVTD 281

  Fly   217 TPLELLG-----------CPLPLGDERPILTGDGSRVLTGPITRGTVRFSCKQGY-VLEG----- 264
            ...:..|           ||.|:...    .|..|.|....|.:.:....|:.|| :|:|     
Human   282 ESGDHTGWKIHYTSTAQPCPYPMAPP----NGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLK 342

  Fly   265 EESSYCAKNKWSTSTIPKCVKYCSTAGEFDGYSTKALCTHNGQQVECRKPFHPPGTEVKFVCSTG 329
            ..::.|.|:......:|.|                       ..|:|..|...|...|:::...|
Human   343 SFTAVCQKDGSWDRPMPAC-----------------------SIVDCGPPDDLPSGRVEYITGPG 384

  Fly   330 FKTLSPLPEMRC------MK----------GGYW--NRGRQR---CEQDCGQLATPIKQFSSGGY 373
            ..|...:.:..|      ||          .|:|  ::|.:.   ||..||..|........||.
Human   385 VTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCGLSARTTGGRIYGGQ 449

  Fly   374 TINNTVVPWHV----GLYVWHNEKDYHFQCGGSLLTPDLVITAAHCVYD---EGTRLPYSYDTFR 431
            .......||.|    |.           ...|:||..:.|:||||.||:   :.:.|.....|.:
Human   450 KAKPGDFPWQVLILGGT-----------TAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLK 503

  Fly   432 VIAAKFYRNYGETTPEEKRRDVRLIEIAPGYKGRTENYYQDLALLTLDEPFELSHVIRPICVTFA 496
            .::..:.:.:.|.           :.|..||. ....:..|:||:.|:....::..|.|||:. .
Human   504 RLSPHYTQAWSEA-----------VFIHEGYT-HDAGFDNDIALIKLNNKVVINSNITPICLP-R 555

  Fly   497 SFAEKESVTDDVQGKFAGWNIENK----HELQFVPAVSKSNSVCRRNLR-------DIQADKFC- 549
            ..||....|||: |..:||.:..:    ..|.:|......:..|.....       .:.|:..| 
Human   556 KEAESFMRTDDI-GTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCA 619

  Fly   550 -IFTQGKSLACQGDSGGGFTSELPTNAFSTWNTARHFLFGVIS----NAPNADQCAHSLTVMTNI 609
             :.:.||. :|:|||||..       .|....|.|.|:.|::|    |...|.|......|:..|
Human   620 GLESGGKD-SCRGDSGGAL-------VFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYI 676

  Fly   610 QHFEDMI 616
            ...|::|
Human   677 PWIENII 683

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
modSPNP_536776.2 LDLa 27..58 CDD:197566
LDLa 70..101 CDD:197566 9/32 (28%)
LDLa 123..157 CDD:197566 10/68 (15%)
LDLa 167..199 CDD:238060 5/31 (16%)
CCP <251..284 CDD:153056 8/38 (21%)
Sushi 309..354 CDD:278512 13/65 (20%)
Tryp_SPc 371..616 CDD:214473 63/268 (24%)
Tryp_SPc 371..591 CDD:304450 56/239 (23%)
MASP2NP_006601.2 CUB 28..134 CDD:214483 3/8 (38%)
EGF_CA 138..176 CDD:214542 12/49 (24%)
CUB 184..293 CDD:278839 22/126 (17%)
CCP 300..361 CDD:214478 15/64 (23%)
Sushi 366..430 CDD:278512 12/63 (19%)
Tryp_SPc 444..679 CDD:214473 62/267 (23%)
Tryp_SPc 445..682 CDD:238113 63/269 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.