Protein Alignment Mettl4 and METTL4

DIOPT Version :10

• Sequence 1: NP_650573.1
• Gene: Mettl4 / 42030
• FlyBaseID: FBgn0015351
• Length: 359
• Species: Drosophila melanogaster
• Sequence 2: NP_073751.3
• Gene: METTL4 / 64863
• HGNCID: 24726
• Length: 472
• Species: Homo sapiens
• Alignment Length: 332
• Identity: 106/332 - (31%)
• Similarity: 159/332 - (47%)
• Gaps: 53/332 - (15%)

  Fly    22 LINEAYDEFKLKSELFQFHAKKTDKGIEEDKTRKRKRKAGVEDASSLEDL-----HL--VNEYLE 79
            ||.|.     |||.......:|.|||        .|......||.||.:|     ||  :|| :|
Human   165 LIQEG-----LKSGFLYPLFEKQDKG--------SKPITLPLDACSLSELCEMAKHLPSLNE-ME 215

  Fly    80 LLSKPVEPEDSSPMKRHWEDGYNVPQLHGANESGRMQRFLRVDGSRGVYLIPNQSRFFNHNVDNL 144
            ..:..:..||:|..:   :|.:    |.....:....:.:.:.|.:  ||:|.:|.|...::..:
Human   216 HQTLQLVEEDTSVTE---QDLF----LRVVENNSSFTKVITLMGQK--YLLPPKSSFLLSDISCM 271

  Fly   145 PALLHQLLPAYDLIVLDPPWRNKYIRRLKRAKPELGYSMLSNEQLSHIPLSKLTHPRSLVAIWCT 209
            ..||: ....:|:||:||||:||.::|..|      ||.||..|:..||:.||..|..|:..|.|
Human   272 QPLLN-YRKTFDVIVIDPPWQNKSVKRSNR------YSYLSPLQIQQIPIPKLAAPNCLLVTWVT 329

  Fly   210 NSTLHQLALEQQLLPSWNLRLLHKLRWYKLSTDHELIAPPQSDLTQKQPYEMLYVACRSD----- 269
            |...|...::::|.|||::.::.:..|.|::...|.:.|  .|...|:|||.|.:....:
Human   330 NRQKHLRFIKEELYPSWSVEVVAEWHWVKITNSGEFVFP--LDSPHKKPYEGLILGRVQEKTALP 392

  Fly   270 ---ASENYGKDIQQTELIFSVPSIVHSHKPPLLSWLREHLLLDKDQLEPNCLELFARYLHPHFTS 331
               |..|. ..|...:||.|||..:|||||||...|::::..|.:.     ||||||.|.|.:||
Human   393 LRNADVNV-LPIPDHKLIVSVPCTLHSHKPPLAEVLKDYIKPDGEY-----LELFARNLQPGWTS 451

  Fly   332 IGLEVLK 338
            .|.||||
Human   452 WGNEVLK 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mettl4	NP_650573.1	MT-A70	155..335	CDD:368270	68/187 (36%)
METTL4	NP_073751.3	MT-A70	281..455	CDD:470404	68/187 (36%)