DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14906 and mettl4

DIOPT Version :9

Sequence 1:	NP_650573.1	Gene:	CG14906 / 42030	FlyBaseID:	FBgn0015351	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	XP_689178.3	Gene:	mettl4 / 560686	ZFINID:	ZDB-GENE-130129-2	Length:	450	Species:	Danio rerio

Alignment Length:	280	Identity:	89/280 - (31%)
Similarity:	135/280 - (48%)	Gaps:	31/280 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 LSKPVEPEDSSPMKRHWEDGYN-VPQLHGANESGRMQRFLRVDGSRGVYLIPNQSRFFNHNVDNL 144
            |:|.:...:.||:.....||.| ...|..:...........:...|..||:|.:.||...:|..:
Zfish   161 LAKQLPLSEESPVHTLSRDGQNPALDLFSSITENPFDCACEITFMRERYLLPPRCRFLLSDVTRM 225

  Fly   145 PALLHQLLPAYDLIVLDPPWRNKYIRRLKRAKPELGYSMLSNEQLSHIPLSKLTHPRSLVAIWCT 209
            ..|::. ...:|||||||||.||.::|..|      ||.|.:.||..:|:..|..|..||..|.|
Zfish   226 DPLVNS-GDKFDLIVLDPPWENKSVKRSNR------YSSLPSSQLKKLPVPALAAPGGLVVTWVT 283

  Fly   210 NSTLHQLALEQQLLPSWNLRLLHKLRWYKLSTDHELIAPPQSDLTQKQPYEMLYVA-CRSDASE- 272
            |...|:..:.::|.|.|.:.:|.:..|.|::...|.:.|  .|...|:|||:|.:. |||.:..
Zfish   284 NRAKHRRFVREELYPHWAVEVLAEWLWVKVTRSGEFVFP--LDSQHKKPYEVLVLGRCRSTSDHT 346

  Fly   273 ---NYGKDIQQTELIFSVPSIVHSHKPPLLSWLREHLLLDKDQLEPNCLELFARYLHPHFTSIGL 334
               :...::....|:.||||.:|||||.|.:.|:.::     :.||.|||||||.|...::..|.
Zfish   347 DRCSAVNELPDQRLLVSVPSTLHSHKPSLAAVLKPYI-----RREPRCLELFARSLQSDWSCWGN 406

  Fly   335 EVLKLMDERLYEVRKVEHCN 354
            ||||.           :||:
Zfish   407 EVLKF-----------QHCS 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14906	NP_650573.1	MT-A70	155..335	CDD:282866	67/184 (36%)
mettl4	XP_689178.3	MT-A70	235..407	CDD:295100	67/184 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576224
Domainoid	1	1.000	116	1.000	Domainoid score	I5932
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H35305
Inparanoid	1	1.050	129	1.000	Inparanoid score	I4637
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1496188at2759
OrthoFinder	1	1.000	-	-		FOG0004635
OrthoInspector	1	1.000	-	-		oto38664
orthoMCL	1	0.900	-	-		OOG6_105628
Panther	1	1.100	-	-	LDO	PTHR12829
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1688
SonicParanoid	1	1.000	-	-		X3250
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.930