DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT3 and CCT3

DIOPT Version :9

Sequence 1:	NP_001189236.1	Gene:	CCT3 / 42029	FlyBaseID:	FBgn0015019	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_012520.1	Gene:	CCT3 / 853438	SGDID:	S000003551	Length:	534	Species:	Saccharomyces cerevisiae

Alignment Length:	537	Identity:	322/537 - (59%)
Similarity:	410/537 - (76%)	Gaps:	18/537 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QQPILVLSQNTKRESGRKVQLENIQAGKAIADVIRTCLGPQAMLKMLMDPMGGIVMTNDGNAILR 69
            |.|::.::.:.:|.:||:.|:.||.|.||:||||||||||:||||||:|||||:|:||||:||||
Yeast     2 QAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILR 66

  Fly    70 EITVQHPAAKSMIEIARTQDEEVGDGTTSVIVLAGEMLAAAEPFL-QQQIHPTVIIRAYREALED 133
            ||.|.|||||||:|::||||||||||||:||:||||:||...|:| ::.|||.:||:|.::||.|
Yeast    67 EIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTD 131

  Fly   134 IVGHLQSQLSIQLDVKDKAKMADVVKACVGTKFIGKWSDLAVKIALDAVETV------TLSENGR 192
            .: .:..|:|..:||::.|.|..:::|.:|||::..||:...::|||||:||      |:.....
Yeast   132 AL-EVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQTVEGEPN 195

  Fly   193 LEVDIKRYAKVEKIPGGAIEESCVLKGVMINKDVTHPKMRRLIENPRIVLLDCSLEYKKGESQTN 257
            .|:|||||.:|||||||.:.:|.|||||::||||.||||.|.|||||:|||||.|||||||||||
Yeast   196 FEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTN 260

  Fly   258 VEIIGEQDFTRMLQIEEEFVQRICADIIAVKPDLVFTEKGVSDLAQHYLLKAGITAIRRLRKTDN 322
            :||..|:|:.|:||||||.||.:|..|:||:|.||.|||||||||||||||.|.:.:||::|:||
Yeast   261 IEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDN 325

  Fly   323 LRIARACGATIVNRTEELTEKDVGTGAGLFEVKKIGDEYFTFVTECKEPKACTILLRGASKDILN 387
            .||||..|||||||.|:|.|.||||..|||:|:.||||||:|:..|||||||||:|||.||||||
Yeast   326 NRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILN 390

  Fly   388 ETERNLQDALHVARNLVLEPRLVAGGGAVEMAASQLLTR--KQVKG----PYTAVAHALEIIPRT 446
            |.:||||||:.||||::|.|.|..||||.|||.|..|..  ||::|    ||.|||.|:|.||||
Yeast   391 EIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRT 455

  Fly   447 LAQNCGANTIRALTALRAKHASHTGDGVCAWGIDGESGEIVDMNVKNIWEPLAVKLQTYKTAVET 511
            |.||.|.:.||.|:.||||||    .|....||||:.|:||||....||||..:|.|:.|||:|:
Yeast   456 LIQNAGGDPIRLLSQLRAKHA----QGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIES 516

  Fly   512 AILLLRIDDIVSGSKKR 528
            |.||||:||||||.:|:
Yeast   517 ACLLLRVDDIVSGVRKQ 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT3	NP_001189236.1	chap_CCT_gamma	7..528	CDD:274085	320/533 (60%)
CCT3	NP_001189236.1	TCP1_gamma	7..524	CDD:239453	318/529 (60%)
CCT3	NP_012520.1	chap_CCT_gamma	4..533	CDD:274085	321/535 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341309
Domainoid	1	1.000	588	1.000	Domainoid score	I28
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4373
Inparanoid	1	1.050	618	1.000	Inparanoid score	I123
Isobase	1	0.950	-	0	Normalized mean entropy	S97
OMA	1	1.010	-	-		QHG53994
OrthoFinder	1	1.000	-	-		FOG0004601
OrthoInspector	1	1.000	-	-		oto99575
orthoMCL	1	0.900	-	-		OOG6_100235
Panther	1	1.100	-	-	LDO	PTHR11353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1488
SonicParanoid	1	1.000	-	-		X3218
TreeFam	1	0.960	-	-
	16	15.740