DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT3 and CCT6

DIOPT Version :9

Sequence 1:	NP_001189236.1	Gene:	CCT3 / 42029	FlyBaseID:	FBgn0015019	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_010474.3	Gene:	CCT6 / 851768	SGDID:	S000002596	Length:	546	Species:	Saccharomyces cerevisiae

Alignment Length:	541	Identity:	145/541 - (26%)
Similarity:	270/541 - (49%)	Gaps:	38/541 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SQNTKRESGRKVQLENIQAGKAIADVIRTCLGPQAMLKMLMDPMGGIVMTNDGNAILREITVQHP 76
            :::.:|::..||   |:.:.:.:..|:.|.|||:..||||:|..|.|.:|.||..:|.|:.:|.|
Yeast    10 AESLRRDAALKV---NVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSP 71

  Fly    77 AAKSMIEIARTQDEEVGDGTTSVIVLAGEMLAAAEPFLQQQIHPTVIIRAYREALEDIVGHL--- 138
            .|..:...|..|||..|||||:|:.|.||:|..|..|:|:.:||.:|...:..|.::.:..|
Yeast    72 TAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEF 136

  Fly   139 ---QSQLSIQLDVKDKAKMADVVKACVGTKFIGKWSDLAVKIALDAVETVTLSENGRLEVDIKRY 200
               ::.||     .|:..:..|.::.:.||.....:::...|..|||.:|..::...|::.:...
Yeast   137 KISKTNLS-----NDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMVEI 196

  Fly   201 AKVEKIPGGAIEESCVLKGVMINKDVTHPKMRRLIENPRIVLLDCSLEYKKGESQTNVEIIGEQD 265
            .:::.:   :.:::..:||::::....||.|...::|..:::|:.||||:|.|..:.........
Yeast   197 MQMQHL---SPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQ 258

  Fly   266 FTRMLQIEEEFVQRICADIIAVK-------PD---LVFTEKGVSDLAQHYLLKAGITAIRRLRKT 320
            ..::...|.:||......||.:|       ||   ::..:||:..::.....|..|.|:||.::.
Yeast   259 RDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILALRRAKRR 323

  Fly   321 DNLRIARACGATIVNRTEELTEKDVGTGAGLFEVKKIGDEYFTFVTECKEPKACTILLRGASKDI 385
            :..|:....|....|..|:|:.:.:|. :||...:.||:|.||:|||..:||:||||::|::...
Yeast   324 NMERLQLVTGGEAQNSVEDLSPQILGF-SGLVYQETIGEEKFTYVTENTDPKSCTILIKGSTHYA 387

  Fly   386 LNETERNLQDALHVARNLVLEPRLVAGGGAVEMAASQLL---------TRKQVKGPYTAVAHALE 441
            |.:|:..::|.|....|::.:..::.|.||..:|.|:.|         .:.:.|....|.|.||.
Yeast   388 LAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALL 452

  Fly   442 IIPRTLAQNCGANTIRALTALRAK-HASHTGDGVCAWGIDGESGEIVDMNVKNIWEPLAVKLQTY 505
            :||:||.:|.|.:.:..|..:..: ..:...|.....|:|...|:..|..::.||:...|.....
Yeast   453 VIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAI 517

  Fly   506 KTAVETAILLLRIDDIVSGSK 526
            ..|...|..||..|:::...:
Yeast   518 TGATGIASNLLLCDELLRAGR 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT3	NP_001189236.1	chap_CCT_gamma	7..528	CDD:274085	145/541 (27%)
CCT3	NP_001189236.1	TCP1_gamma	7..524	CDD:239453	145/537 (27%)
CCT6	NP_010474.3	chap_CCT_zeta	2..542	CDD:274088	145/541 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810