DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT3 and CCT4

DIOPT Version :9

Sequence 1:	NP_001189236.1	Gene:	CCT3 / 42029	FlyBaseID:	FBgn0015019	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_010138.1	Gene:	CCT4 / 851412	SGDID:	S000002302	Length:	528	Species:	Saccharomyces cerevisiae

Alignment Length:	534	Identity:	161/534 - (30%)
Similarity:	289/534 - (54%)	Gaps:	52/534 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RESGRKVQLENIQAGKAIADVIRTCLGPQAMLKMLMDPMGGIVMTNDGNAILREITVQHPAAKSM 81
            :|..::|:..||.|.:::||.|||.|||:.|.||:....|.|:::|||:.||:::.:.||.|:.:
Yeast    14 KEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARML 78

  Fly    82 IEIARTQDEEVGDGTTSVIVLAGEMLAAAEPFLQQQIHPTVIIRAYREALEDIVGHLQSQLSIQL 146
            :|::..||.|.|||||||::|.|.:|.|||..|.:.||||:|..:::.|.:..|..| .::..::
Yeast    79 VEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDIL-LEMCHKV 142

  Fly   147 DVKDKAKMADVVKACVGTKFIGKWSDLAVKIALDAVETVTLSENGRLEVDIKRYAKVEKIPGGAI 211
            .:.|:.::.......:.:|.:.::|.....:|:|:|  :.:|:.....||:.....|:|: ||.|
Yeast   143 SLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSV--LKISDENSKNVDLNDIRLVKKV-GGTI 204

  Fly   212 EESCVLKGVMIN----KDVTHPKMRRLIENPRIVLLDCSLEYKKGESQTNVEIIGEQDFTRMLQI 272
            :::.::.||::.    |....|..:   |..:|.|:...:...|.:::.|:.:...:...::|:.
Yeast   205 DDTEMIDGVVLTQTAIKSAGGPTRK---EKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKE 266

  Fly   273 EEEFVQRICADIIAVKPDLVFTEK-----GVSDLAQHYLLKAGITAIRRLRKTDNLRIARACGAT 332
            |..::..||..|...|.:::..:|     .|:|||.|:|.|..|..::.:.:.:...:::..|..
Yeast   267 ERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLGCK 331

  Fly   333 IVNRTEELTEKDVGTGAGLFEVKKIGDEYFTFVTECKEPKA---CTILLRGASKDILNETERNLQ 394
            .:...|..||..:|:...:.|:...|.: ...||..:...|   .::::|||:..|::||||:|.
Yeast   332 PIADIELFTEDRLGSADLVEEIDSDGSK-IVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLH 395

  Fly   395 DALHVARNLVLEPRLVAGGGAVEMAASQLLTR--KQVKGPYTAV----AHALEIIPRTLAQNCGA 453
            |||.|.|.||.|..|:|||||.|:..|:.|::  :.::|....:    |.|||:||.|||:|.|.
Yeast   396 DALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGL 460

  Fly   454 NTIRALTALRAKHASHTGDGVCAWGIDGESGEIVD-MNVK----------NIWEPLAVKLQTYKT 507
            |:|:.:|.||:||               |:||:.| ::|:          :|.:|:.|.......
Yeast   461 NSIKVVTELRSKH---------------ENGELNDGISVRRSGTTNTYEEHILQPVLVSTSAITL 510

  Fly   508 AVETAILLLRIDDI 521
            |.|....:||||||
Yeast   511 ASECVKSILRIDDI 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT3	NP_001189236.1	chap_CCT_gamma	7..528	CDD:274085	161/534 (30%)
CCT3	NP_001189236.1	TCP1_gamma	7..524	CDD:239453	161/534 (30%)
CCT4	NP_010138.1	chap_CCT_delta	11..528	CDD:274083	161/534 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810