DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT3 and HSP60

DIOPT Version :9

Sequence 1:	NP_001189236.1	Gene:	CCT3 / 42029	FlyBaseID:	FBgn0015019	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_013360.1	Gene:	HSP60 / 850963	SGDID:	S000004249	Length:	572	Species:	Saccharomyces cerevisiae

Alignment Length:	614	Identity:	129/614 - (21%)
Similarity:	226/614 - (36%)	Gaps:	145/614 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QPILVLSQNTKRE-----SGRKVQLENIQAGKAIADVIRTCLGPQAMLKMLMDPMGGIVMTNDGN 65
            :|:|..:.::.:|     .||...|:.::   .:|:.:...|||:....::..|.|...:|.||.
Yeast    14 RPLLRRAYSSHKELKFGVEGRASLLKGVE---TLAEAVAATLGPKGRNVLIEQPFGPPKITKDGV 75

  Fly    66 AILREITV----QHPAAKSMIEIARTQDEEVGDGTTSVIVLAGEMLAAAEPFLQQQIHPTVIIRA 126
            .:.:.|.:    ::..||.:.|:|...:|..||||||..||...:...:...:....:|..:.|.
Yeast    76 TVAKSIVLKDKFENMGAKLLQEVASKTNEAAGDGTTSATVLGRAIFTESVKNVAAGCNPMDLRRG 140

  Fly   127 YREALEDIVGHLQSQLSIQLDVKDKAKMADVVKACVGTKFIGKWSDLAV-KIALDAVETVTLSEN 190
            .:.|:|.::..|.:........::.|::|.:  :..|...:||....|: |:..:.|  :|:.|.
Yeast   141 SQVAVEKVIEFLSANKKEITTSEEIAQVATI--SANGDSHVGKLLASAMEKVGKEGV--ITIREG 201

  Fly   191 GRLEVDIKRYAKVEKIPGGAIEESCVLKGVMINKD------VTHPKMRRL-IENPRIVLLDCSLE 248
            ..||.:::                 |.:|:..::.      :|.||..:: .|.|.::|.:
Yeast   202 RTLEDELE-----------------VTEGMRFDRGFISPYFITDPKSSKVEFEKPLLLLSE---- 245

  Fly   249 YKKGESQTNV----EIIGEQDFTRMLQIEEEFVQ----------------RICA----------- 282
             ||..|..::    ||..:.  .|.|.|..|.|.                ::||
Yeast   246 -KKISSIQDILPALEISNQS--RRPLLIIAEDVDGEALAACILNKLRGQVKVCAVKAPGFGDNRK 307

  Fly   283 ----DIIAVKPDLVFTEKGVSDLAQHYLLKAGITAIRRLRKTDNLRIARACGATIVNRT------ 337
                ||..:....||||:        ..||.....|..|...|::.:.:. ...|:|.:
Yeast   308 NTIGDIAVLTGGTVFTEE--------LDLKPEQCTIENLGSCDSITVTKE-DTVILNGSGPKEAI 363

  Fly   338 EELTEKDVG----TGAGLFEVKKIGDEYFTFVTECKEPKACTILLRGASKDILNETERNLQDALH 398
            :|..|:..|    |....:|.:|:.:.....     ......|.:.|||:..:.|.:....|||:
Yeast   364 QERIEQIKGSIDITTTNSYEKEKLQERLAKL-----SGGVAVIRVGGASEVEVGEKKDRYDDALN 423

  Fly   399 VARNLVLEPRLVAGGGAVEMAASQLLTRKQVKGPYTAVAHALEIIPRTLAQNCGANTIRALTALR 463
            ..|..| |..::.|||...:.||::|.               |::.....|..|.:.||......
Yeast   424 ATRAAV-EEGILPGGGTALVKASRVLD---------------EVVVDNFDQKLGVDIIRKAITRP 472

  Fly   464 AK----HASHTGDGVC-----------AWGIDGESGEIVDMNVKNIWEPLAVKLQTYKTAVETAI 513
            ||    :|...|..:.           |.|.|....|..||....|.:|..|.......|...|.
Yeast   473 AKQIIENAGEEGSVIIGKLIDEYGDDFAKGYDASKSEYTDMLATGIIDPFKVVRSGLVDASGVAS 537

  Fly   514 LLLRIDDIVSGSKKRGGNEPTNPAAMAQG 542
            ||...:..:.       :.|..|||...|
Yeast   538 LLATTEVAIV-------DAPEPPAAAGAG 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT3	NP_001189236.1	chap_CCT_gamma	7..528	CDD:274085	124/597 (21%)
CCT3	NP_001189236.1	TCP1_gamma	7..524	CDD:239453	124/593 (21%)
HSP60	NP_013360.1	GroEL	25..548	CDD:239460	122/590 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810