DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCT3 and Mkks

DIOPT Version :9

Sequence 1:	NP_001189236.1	Gene:	CCT3 / 42029	FlyBaseID:	FBgn0015019	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001135418.1	Gene:	Mkks / 59030	MGIID:	1891836	Length:	570	Species:	Mus musculus

Alignment Length:	557	Identity:	121/557 - (21%)
Similarity:	216/557 - (38%)	Gaps:	93/557 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 VIRTCLGPQAMLKMLMDPMGGIV-MTNDGNAILREITVQHPAAKSMIEIARTQDEEVGDGTTSVI 100
            ||.:|.||...||.|.:.:||.| .|:..:|:||.::|.||..|.:....:.......|......
Mouse    32 VIASCYGPSGRLKQLHNGLGGCVYTTSQSSALLRNLSVTHPVLKILTSSVQNHVSCFSDCGLFTA 96

  Fly   101 VLAGEMLAAAEPFLQQQIHPTVIIRAYREALEDIVGHLQSQ---LSIQLDVKDKAKMADVV---- 158
            :|...::   |...:..:.|...|:..:..|.....:|:|:   ..|.:|.:.......:|
Mouse    97 ILCCNLI---ENIQRLDLTPATAIKLNKYLLSLCTSYLKSEACSCRIPVDFRSTHTFLSLVHSIL 158

  Fly   159 ---KACVGTKFIGKWSDLAVKIALDA-VETVTLSENGRLEVDIKRYAKVEKIPGGAIEESCVLKG 219
               .||:.|:   |.:|....:.|.| :.|:..|...|:   :...:.:..:.|..:.:|.||.|
Mouse   159 TSKPACMLTR---KETDHIGALILKAFLLTIPESTEERM---VLGKSIIVPLKGQRVTDSTVLPG 217

  Fly   220 VMINKDVTHPKMRRLIENP-----RIVLLDCSLEYKKGESQTNVEIIGEQDFTRMLQIEE--EFV 277
            ::|  :.:..::|||:...     |:.|...||......:...|.:...|.......:|:  ...
Mouse   218 LLI--EASEVQLRRLLPTQKASGLRVALFCTSLSGDFSNAGEGVVVAHYQVSLENAVLEQLLNLG 280

  Fly   278 QRICADIIAVKPDLVFTEKGVSDLAQHYLLKAGITAIRRLRKTDNLRIARACGATIVNRTEELTE 342
            :|:..|.:    |||..:|.:....:.:..:..:.||.|:..|....:::..|||.:.....:..
Mouse   281 RRLVTDHV----DLVLCQKVIHPSLKQFFSERHVMAIDRVGVTLMESLSKVTGATPIGSLNPIVS 341

  Fly   343 KDVGTGAGLFEVK-----KIGDEYFTFVTECKEPKACTILLRGASKDILNETERNLQDALHVARN 402
            ...|:      ||     :.|.::| |.....|...||:||...:.....|.:...|.|:||.:.
Mouse   342 TTYGS------VKDVCSARFGSKHF-FHLLPNEATVCTLLLCSRNDTAWEELKLTCQTAMHVLQL 399

  Fly   403 LVLEPRLVAGGGAVEMAASQLLTRK---------------QVKGPYTAVA--HALEIIPRTLAQN 450
            .:.||.::.|||..|...:..:..|               |.|....|.|  .|||.:..:|..:
Mouse   400 TIKEPWVLLGGGCTETHLAAYVRHKVHHEAEAIVRDDGCTQAKLHVAAEAFCSALESVAGSLEHD 464

  Fly   451 CGANTIRA----LTALRAKHAS--HTGDGV--CAWGIDGESGEIVDMNVKNIWEPLA-------- 499
            .|...|..    |.:.:|..||  :..|.:  |..|:.....|:....:::.:.|.|
Mouse   465 GGEILIDTKYGHLWSCQADSASVGNWSDTLSRCGCGLYNSQEELSWSVLRSTYHPFAPQTCLPQA 529

  Fly   500 --------------VKLQTYKTAVETAILLLRIDDIV 522
                          .||...:.|||||.|:|.:..::
Mouse   530 ALGSASNLTVDCFTAKLSGLQVAVETANLILDLSYVI 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT3	NP_001189236.1	chap_CCT_gamma	7..528	CDD:274085	121/557 (22%)
CCT3	NP_001189236.1	TCP1_gamma	7..524	CDD:239453	121/557 (22%)
Mkks	NP_001135418.1	Cpn60_TCP1	29..569	CDD:395068	121/557 (22%)
Mkks	NP_001135418.1	Substrate-binding apical domain. /evidence=ECO:0000250\|UniProtKB:Q9NPJ1	198..370		36/184 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810