DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT3 and cct2

DIOPT Version :9

Sequence 1:	NP_001189236.1	Gene:	CCT3 / 42029	FlyBaseID:	FBgn0015019	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001006757.1	Gene:	cct2 / 448434	XenbaseID:	XB-GENE-1006535	Length:	535	Species:	Xenopus tropicalis

Alignment Length:	562	Identity:	164/562 - (29%)
Similarity:	277/562 - (49%)	Gaps:	82/562 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PILVLSQNTKRESGRKVQLENIQAGKAIADVIRTCLGPQAMLKMLMDPMGG----IVMTNDGNAI 67
            |:.:.......|.....:|.:.....||.|::::.|||:.|.|:|:.  .|    :.:||||..|
Frog     8 PVNIFKAGADEEKAETARLSSFIGAIAIGDLVKSTLGPKGMDKILLS--SGRDSTVTVTNDGATI 70

  Fly    68 LREITVQHPAAKSMIEIARTQDEEVGDGTTSVIVLAGEMLAAAEPFLQQQIHPTVIIRAYREA-- 130
            |:.|.:.:|||:.::::::.||:|||||||||.|||.|:|..||..:.::|||..||..:|:|
Frog    71 LKAIGIDNPAAQVLVDMSKVQDDEVGDGTTSVTVLAAELLREAEVLVARKIHPQTIISGWRQATQ 135

  Fly   131 ------LEDIVGHLQSQLSIQLDVKDKAKMADVVKACVGTKFIGKWSDLAVKIALDAVETVTLSE 189
                  |...|.|...:...:.|      :.::.:..:.:|.:....|...|:|::||  :.|..
Frog   136 VAREALLNASVDHGNDEEKFRCD------LLNIARTTLSSKLLTHHKDHFSKLAVEAV--LRLKG 192

  Fly   190 NGRLEVDIKRYAKVEKIPGGAIEESCVLKGVMINK--DVTHPKMRRLIENPRIVLLDCSLEYKKG 252
            :|.||.     ..|.|..||::.||.:.:|.:::|  .|..||.   |||.:|::.:..::..|
Frog   193 SGNLEA-----IHVIKKLGGSLTESYLDEGFLLDKKIGVNQPKR---IENAKILIANTGMDTDK- 248

  Fly   253 ESQTNVEIIGEQ---DFT-RMLQIE-------EEFVQRI------C---ADIIAVKPDLVFTEKG 297
                 ::|.|.:   |.| ::.:||       :|.|:||      |   ..:|...|:.:|...|
Frog   249 -----IKIFGSRVRVDSTAKVAEIELAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFATAG 308

  Fly   298 VSDLAQHYLLKAGITAIRRLRKTDNLRIARACGATIVNRTEELTEKDVGTGAGLFEVKKIGDEYF 362
            |  :|..:...||:.           |:|...|..|.:..:......:|| ..|.|...||::..
Frog   309 V--MAIEHADFAGVE-----------RLALVTGGEIASTFDHPELVKLGT-CKLIEEVMIGEDKL 359

  Fly   363 TFVTECKEPKACTILLRGASKDILNETERNLQDALHVARNLVLEPRLVAGGGAVEMAASQLLTRK 427
            ...:.....:||||:||||::.||:|.||:|.|||.|....|.:.|.|.|||..||..:..:|..
Frog   360 IHFSGVAMGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDTRTVYGGGCSEMLMAHAVTEL 424

  Fly   428 QVKGP------YTAVAHALEIIPRTLAQNCGANTIRALTALRAKHASHTGDGVCAWGIDGESGEI 486
            .::.|      ..:.|.||.::|..:|.|.|.::...::.|||.|:    :|...:|:|.::|.|
Frog   425 AIRTPGKESVAMESFAKALRMLPTIIADNAGYDSADLVSQLRAAHS----EGKSTYGLDMKNGTI 485

  Fly   487 VDMNVKNIWEPLAVKLQTYKTAVETAILLLRIDDIVSGSKKR 528
            .:|....|.|...||.|...:|.|.|.::||:|:|:..:.::
Frog   486 GEMGELGITESFQVKRQVLLSASEAAEVILRVDNIIKAAPRK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT3	NP_001189236.1	chap_CCT_gamma	7..528	CDD:274085	164/560 (29%)
CCT3	NP_001189236.1	TCP1_gamma	7..524	CDD:239453	164/556 (29%)
cct2	NP_001006757.1	TCP1_beta	11..527	CDD:239452	163/557 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910