DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT3 and cct5

DIOPT Version :9

Sequence 1:	NP_001189236.1	Gene:	CCT3 / 42029	FlyBaseID:	FBgn0015019	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_989340.1	Gene:	cct5 / 394966	XenbaseID:	XB-GENE-980275	Length:	541	Species:	Xenopus tropicalis

Alignment Length:	530	Identity:	180/530 - (33%)
Similarity:	293/530 - (55%)	Gaps:	21/530 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GQQPILVLSQNTK-RESGRKVQLENIQAGKAIADVIRTCLGPQAMLKMLMDPMGGIVMTNDGNAI 67
            |:..|::..|:.| |.||......:|.|.||:|:.:||.|||..:.||::|..|.:.:||||..|
Frog    13 GRPFIIIKDQDRKSRLSGLDALKSHIMAAKAVANTLRTSLGPNGLDKMMVDKDGQVTVTNDGATI 77

  Fly    68 LREITVQHPAAKSMIEIARTQDEEVGDGTTSVIVLAGEMLAAAEPFLQQQIHPTVIIRAYREALE 132
            |..:.|.|..||.|:|::::||:|:|||||.|:||||.:|..||..|.:.|||..|...|.:|..
Frog    78 LSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEQAEQLLDRGIHPIRIADGYEQAAR 142

  Fly   133 DIVGHLQS-QLSIQLDVKDKAKMADVVKACVGTKFIGKWSDLAVKIALDAVETVTLSENGRLEVD 196
            ..|.||.. ..|..:|.::...:.......:|:|.|.:......:||::::  :|:::..|.:||
Frog   143 IAVEHLDKISDSFPVDPENLEPLIRTAMTTLGSKVINRCHRQMAEIAVNSI--LTVADMDRKDVD 205

  Fly   197 IKRYAKVEKIPGGAIEESCVLKGVMINKDVTHPKMRRLIENPRIVLLDCSLEYKKGESQTNVEII 261
            .: ..|||...||.:|::.::|||:::||.:||:|.:::::.:|.:|.|..|..|.:::..:::.
Frog   206 FE-LIKVEGKVGGKLEDTQLIKGVIVDKDFSHPQMPKVVKDAKIAILTCPFEPPKPKTKHKLDVT 269

  Fly   262 GEQDFTRMLQIEEEFVQRICADIIAVKPDLVFTEKGVSDLAQHYLLKAGITAIRRLRKTDNLRIA 326
            ..:|:..:.:.|:|....:...|.....:|...:.|..|.|.|.||:..:.|:|.:...:...||
Frog   270 SVEDYKALQKYEKEKFLEMVKQIKDTGANLAICQWGFDDEANHLLLQNELPAVRWVGGPEIELIA 334

  Fly   327 RACGATIVNRTEELTEKDVGTGAGLFEVKKIG----DEYFTFVTECKEPKACTILLRGASKDILN 387
            .|.|..||.|..|||.:.:|. ||:  ||:|.    .:....:.:||..:|.||.:||.:|.|:.
Frog   335 IATGGRIVPRFCELTPEKLGY-AGI--VKEISFGTTKDRMLVIEQCKNSRAVTIFIRGGNKMIIE 396

  Fly   388 ETERNLQDALHVARNLVLEPRLVAGGGAVEMAASQLLTRKQVKGP------YTAVAHALEIIPRT 446
            |.:|:|.|||.|.||||.:.|:|.||||.|::.:..::....|.|      ..|.|.||||||.:
Frog   397 EAKRSLHDALCVIRNLVRDNRIVYGGGAAEISCALAVSEAADKCPSLEQYAMRAFADALEIIPMS 461

  Fly   447 LAQNCGANTIRALTALRAKHASHTGDGVCAWGIDGESGEIVDMNVKNIWEPLAVKLQTYKTAVET 511
            ||:|.|.|.|:.:|.:|:|....:..   |.|||.......||..:::.|.|..|.|....|.:.
Frog   462 LAENSGMNPIQTMTEVRSKQVKESNP---ALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQV 523

  Fly   512 AILLLRIDDI 521
            ..::|:||||
Frog   524 VKMILKIDDI 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT3	NP_001189236.1	chap_CCT_gamma	7..528	CDD:274085	179/527 (34%)
CCT3	NP_001189236.1	TCP1_gamma	7..524	CDD:239453	179/527 (34%)
cct5	NP_989340.1	TCP1_epsilon	10..535	CDD:239455	180/530 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920