DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCT3 and fab1

DIOPT Version :9

Sequence 1:	NP_001189236.1	Gene:	CCT3 / 42029	FlyBaseID:	FBgn0015019	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_611269.1	Gene:	fab1 / 37033	FlyBaseID:	FBgn0028741	Length:	1809	Species:	Drosophila melanogaster

Alignment Length:	334	Identity:	80/334 - (23%)
Similarity:	143/334 - (42%)	Gaps:	38/334 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 VDIKRYAKVEKIPGGAIEESCVLKGVMINKDVTHPKMRRLIENPRIVLLDCSLEYKKGESQ-TNV 258
            :||:.|...:|:|||..::|.::.||..:|:|.|..|...:..|||:||.|.:.|::.|.: ..:
  Fly   505 MDIRNYVNFKKVPGGRRKDSKIVHGVAFSKNVAHKDMATHVPFPRILLLQCPIVYERIEGKFVTI 569

  Fly   259 EIIGEQDFTRMLQIEEEFVQRICADIIAVKPDLVFTEKGVSDLAQHYLLKAGITAIRRLRKTDNL 323
            |       |.:|| |:|:::.:||.|::.||::|...|.|:.:||..|....:|.:..::.:...
  Fly   570 E-------TVLLQ-EKEYLRNVCARIMSFKPNVVLVHKNVAGIAQDLLRSYEVTLVLDVKLSVME 626

  Fly   324 RIARACGATIVNRTE-ELTEKDVGTGAGLFEVKKIGDEYFTFVTECKEPKACTILLRGASKDILN 387
            |::|.....||:..| .:|...:|. ...|.::....:...|..:...|:..|.||||.|...|.
  Fly   627 RLSRTLQCDIVSSIESNITMPKLGY-CNDFYIRNYNGKTLMFFEKLTNPRGYTCLLRGGSNAELT 690

  Fly   388 ETERNLQDALHVARNLVLEPRLVAGGGAVEMAASQLLTRKQVKGPYTAVAHALEIIPRTLAQNCG 452
            ..:|.....|....|..||...:....|..::....:...:...|.|.....|......:.:...
  Fly   691 RVKRVASALLFARYNWRLEMSFLLNEFAQPLSPKPSIFDSKETSPKTETEAELRSKRPIILERKS 755

  Fly   453 ANTIRALTA---------LRAKHASHTGDGVCAWGIDGESGEIVDMNVKNIWEPLAVKLQ---TY 505
            .:.|..:.:         |||..|.......||               ..:.|.|||:.:   .:
  Fly   756 EDKITTIVSENVSDFTDPLRASQAEALSTSPCA---------------PPVVEALAVEPRYDNRF 805

  Fly   506 KTAVETAIL 514
            :||:.:.:|
  Fly   806 RTALSSTLL 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT3	NP_001189236.1	chap_CCT_gamma	7..528	CDD:274085	80/334 (24%)
CCT3	NP_001189236.1	TCP1_gamma	7..524	CDD:239453	80/334 (24%)
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264
		DEP	329..397	CDD:214489
		Fab1_TCP	464..717	CDD:239450	62/220 (28%)
		PIPKc	1413..1797	CDD:295374
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453476
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930