DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCT3 and Cct6b

DIOPT Version :9

Sequence 1:	NP_001189236.1	Gene:	CCT3 / 42029	FlyBaseID:	FBgn0015019	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_017452911.1	Gene:	Cct6b / 363658	RGDID:	1359453	Length:	543	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	152/530 - (28%)
Similarity:	278/530 - (52%)	Gaps:	52/530 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NIQAGKAIADVIRTCLGPQAMLKMLMDPMGGIVMTNDGNAILREITVQHPAAKSMIEIARTQDEE 91
            ||.|.:.:.||:|..|||:..||||:...|.|.:|.|||.:|.|:.:|||.|..:.::|..||..
  Rat    23 NICAARGLQDVLRPSLGPKGALKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASIIAKVAAAQDHI 87

  Fly    92 VGDGTTSVIVLAGEMLAAAEPFLQQQIHPTVIIRAY----REALEDIVGHLQSQLSIQLDVKDKA 152
            .||||||.:::.||:|..|:.::.:.:||.:|...:    .:|||     :..::.:|.::| :.
  Rat    88 TGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFDVAKTKALE-----VLDKIKVQKEMK-RE 146

  Fly   153 KMADVVKACVGTKFIGKWSDLAVKIALDAVETVTLSENGRLEVDIKRYAKVE------------- 204
            .:.||.:..:.||...:.:|:..:..:|:|  :.:...| :.:|:.....||
  Rat   147 MLLDVARTSLRTKVHTELADILTEAVVDSV--LAIRRPG-IPIDLFMVEIVEMRHKSETDTQAGD 208

  Fly   205 KIPGGAIEESCVLKGVMINKDVTHPKMRRLIENPRIVLLDCSLEYKKGESQTNVEIIGEQDFTRM 269
            :..|.|:..  :::|::::....||:|::.:::..|::.:.||||:|.|..:.......::..::
  Rat   209 RTQGLALPR--LVRGLVLDHGARHPRMKKQVQDAYILICNVSLEYEKTEVSSGFFYKTVEEKEKL 271

  Fly   270 LQIEEEFV-----------QRICADIIAVKPDLVFTEKGVSDLAQHYLLKAGITAIRRLRKTDNL 323
            ::.|.:|:           |::||:  :.|..:|..:||:..::...|.|..|.|:||.::.:..
  Rat   272 VKAERKFIEDRVQKIIDLKQKVCAE--SNKGFVVINQKGIDPVSLEMLAKHNIVALRRAKRRNLE 334

  Fly   324 RIARACGATIVNRTEELTEKDVGTGAGLFEVKKIGDEYFTFVTECKEPKACTILLRGASKDILNE 388
            |:..|||...||..|:|:|:.:|....:||. .:|:|.|||:.:|..|.:.|:|::|.:|..|.:
  Rat   335 RLTLACGGLAVNSLEDLSEECLGHAGLVFEY-TLGEEKFTFIEDCVNPLSVTLLVKGPNKHTLIQ 398

  Fly   389 TERNLQDALHVARNLVLEPRLVAGGGAVEMAASQLLTRKQ--VKG----PYTAVAHALEIIPRTL 447
            .:..|:|.|...:|.:.:..:|.|.||||:|.::.|...:  |:|    ...|.|.||.|||:.|
  Rat   399 IKDALRDGLRAVKNAIEDGCVVPGAGAVEVAIAEALVNYKHCVQGRARLGIQAFADALLIIPKVL 463

  Fly   448 AQNCGANTIRALTALRAKHASHTGDGVCAWGIDGESGEIVDMNVKNIWEPLAVKLQTYKTAVETA 512
            |||.|.:....|..::.|||    :.....|||..:||.:......||:...||.....:....|
  Rat   464 AQNSGYDLQETLIKIQTKHA----ESKELVGIDLNTGEPMVAAEAGIWDNYCVKKHILHSCTVIA 524

  Fly   513 ILLLRIDDIV 522
            ..:|.:|:|:
  Rat   525 TNVLLVDEIM 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT3	NP_001189236.1	chap_CCT_gamma	7..528	CDD:274085	152/530 (29%)
CCT3	NP_001189236.1	TCP1_gamma	7..524	CDD:239453	152/530 (29%)
Cct6b	XP_017452911.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820