DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT3 and Hsp60C

DIOPT Version :9

Sequence 1:	NP_001189236.1	Gene:	CCT3 / 42029	FlyBaseID:	FBgn0015019	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_608948.2	Gene:	Hsp60C / 33796	FlyBaseID:	FBgn0031728	Length:	576	Species:	Drosophila melanogaster

Alignment Length:	570	Identity:	130/570 - (22%)
Similarity:	224/570 - (39%)	Gaps:	121/570 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GRKVQLENIQAGKAIADVIRTCLGPQAMLKMLMDPMGGIVMTNDGNAILREITV----QHPAAKS 80
            |.:|:...:|....:||.:...:||:....::....|...:|.||..:.:.|.:    |:..||.
  Fly    33 GPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIALKDKFQNIGAKL 97

  Fly    81 MIEIARTQDEEVGDGTTSVIVLAGEMLAAAEPF--LQQQIHPTVIIRAYREALEDIVGHLQSQLS 143
            :.::|...:||.|||||:..|||..:  |.|.|  :.:...|..|.|....|:|.:..:|: :||
  Fly    98 VQDVANNTNEEAGDGTTTATVLARAI--AKEGFEKISRGASPVEIRRGVMLAIETVKDNLR-RLS 159

  Fly   144 IQLDVKDKAKMADVVKACVGTKFIGKW-SDLAVKIALDAVETVTLSENGRLEVDIKRYAKVEKIP 207
            ..::..::......:.| .|.|.:|.. |:...|:..|.|.||   ::|:...|
  Fly   160 RPVNTPEEICQVATISA-NGDKSVGNLISEAIKKVGRDGVITV---KDGKTLCD----------- 209

  Fly   208 GGAIEESCVLKGVMINKDVTHPKMRRLIENPRI-----VLLDCSLEYKKGES-----------QT 256
                 |..|::|:..::....|......:..::     :||.|..:.|...|           :.
  Fly   210 -----ELEVIEGMKFDRGYISPYFINTSKGAKVEFQDALLLFCEKKIKSAPSIVPALELANAQRK 269

  Fly   257 NVEIIGEQDFTRMLQIEEEFVQ-------RICADIIAVKPDLVFTEKGVSDLAQHYLL------- 307
            .:.||.|       .:|.|.:.       ::...:.|||      ..|..|..:..|:
  Fly   270 PLVIIAE-------DLEAEALSTLVVNRLKVGLQVCAVK------APGFGDNRKENLMDMAVATG 321

  Fly   308 ------KAGITAIRRLRKTDNLRIARACGATIVNRTEELTEKDVGTGAGLFEVKK--------IG 358
                  :|.:..:..::.:|..|:    |..:|::.:.:..|..|..|   ||:|        |.
  Fly   322 GIVFGDEANMVRLEDIKMSDFGRV----GEVVVSKDDTMLLKGKGQKA---EVEKRVEGLREAIK 379

  Fly   359 DEYFTFVTECKEPKACTI-----LLR-GASKDI-LNETERNLQDALHVARNLVLEPRLVAGGGAV 416
            :...::..|..:.:...:     ||| |.|.|: ::|.:..:.|||:..|..| |..:|.|||..
  Fly   380 ESTSSYEKEKMQERLARLSSGVALLRVGGSSDVEVSEKKDRVIDALNATRAAV-EEGIVPGGGTA 443

  Fly   417 EMAASQLLTRKQVKGPYTAVAHALEIIPRTLAQNCGANTIRALTALRAKHASHTGDGVCA----- 476
            .:...|.|  ..:||........:|||.|.|...|       ||.  ||:|...|..|.|
  Fly   444 LLRCIQKL--NDLKGANEDQNMGIEIIRRALRMPC-------LTI--AKNAGVDGAMVVAKVEIL 497

  Fly   477 ---WGIDGESGEIVDMNVKNIWEPLAVKLQTYKTAVETAILLLRIDDIVS 523
               :|.|...||..:|..:.|.:|..|.......|...|.||...:.:|:
  Fly   498 DGDYGYDALKGEYGNMIERGIIDPTKVVRTAISDAAGVASLLTTAEAVVT 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT3	NP_001189236.1	chap_CCT_gamma	7..528	CDD:274085	130/570 (23%)
CCT3	NP_001189236.1	TCP1_gamma	7..524	CDD:239453	130/570 (23%)
Hsp60C	NP_608948.2	PTZ00114	23..553	CDD:185455	130/570 (23%)
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	130/570 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453467
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740